Interaction ID
ncRI-40927405
Interaction Molecules
mmu-miR-150-3p -- Fzd4
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Mus musculus
Tissue or Cell Type
P19
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSMUSG00000049791
Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism.
| Pubmed ID | 29084942 | Journal | Nature communications |
|---|---|---|---|
| Title | Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq. | ||
| Author | Bottini S, Hamouda-Tekaya N, Mategot R, Zaragosi LE, Audebert S, Pisano S, Grandjean V, Mauduit C, Benahmed M, Barbry P, Repetto E, Trabucchi M | ||
| Molecule | Disease | Data Source |
|---|---|---|
| mmu-miR-150-3p | Acute Pain | MNDR Database |
| mmu-miR-150-3p | breast cancer | MNDR Database |
| mmu-miR-150-3p | Cardiomegaly | MNDR Database |
| mmu-miR-150-3p | cardiovascular system disease | MNDR Database |
| mmu-miR-150-3p | cerebral malaria | MNDR Database |
| mmu-miR-150-3p | Chemical and Drug Induced Liver Injury | MNDR Database |
| mmu-miR-150-3p | Chronic Pain | MNDR Database |
| mmu-miR-150-3p | Heart Injuries | MNDR Database |
| mmu-miR-150-3p | Huntington's disease | MNDR Database |
| mmu-miR-150-3p | Hyperalgesia | MNDR Database |
| mmu-miR-150-3p | lupus nephritis | MNDR Database |
| mmu-miR-150-3p | medulloblastoma | MNDR Database |
| mmu-miR-150-3p | middle cerebral artery infarction | MNDR Database |
| mmu-miR-150-3p | Myocardial Ischemia | MNDR Database |
| mmu-miR-150-3p | Ophtalmological | MNDR Database |
| mmu-miR-150-3p | osteoporosis | MNDR Database |
| mmu-miR-150-3p | Peripheral Nerve Injuries | MNDR Database |
| mmu-miR-150-3p | Rett syndrome | MNDR Database |
| mmu-miR-150-3p | Seizures | MNDR Database |
| mmu-miR-150-3p | Sepsis | MNDR Database |