ncRI-40926301 - NPInter

Interaction Profile

Interaction ID

ncRI-40926301

Interaction Molecules

mmu-miR-26b-3p -- Fbxl3

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

⇔

Fbxl3

Alias

Class

miRNA

miRBase id

MI0000575

Description

Mus musculus miR-26b stem-loop

Alias

Class

mRNA

Ensembl id

ENSMUSG00000022124

Description

Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.

Reference Information

Pubmed ID	29084942	Journal	Nature communications
Title	Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq.
Author	Bottini S, Hamouda-Tekaya N, Mategot R, Zaragosi LE, Audebert S, Pisano S, Grandjean V, Mauduit C, Benahmed M, Barbry P, Repetto E, Trabucchi M

Network View

Disease Annotation

Molecule	Disease	Data Source
mmu-miR-26b-3p	Alzheimer's disease	MNDR Database
mmu-miR-26b-3p	amyotrophic lateral sclerosis	MNDR Database
mmu-miR-26b-3p	Brain Injury, Chronic	MNDR Database
mmu-miR-26b-3p	Encephalomyelitis, Venezuelan Equine	MNDR Database
mmu-miR-26b-3p	Hyperalgesia	MNDR Database
mmu-miR-26b-3p	medulloblastoma	MNDR Database
mmu-miR-26b-3p	middle cerebral artery infarction	MNDR Database
mmu-miR-26b-3p	Myotonic Dystrophy	MNDR Database
mmu-miR-26b-3p	neurogenic bladder	MNDR Database
mmu-miR-26b-3p	Parkinson's disease	MNDR Database
mmu-miR-26b-3p	Peripheral Nerve Injuries	MNDR Database
mmu-miR-26b-3p	relapsing-remitting multiple sclerosis	MNDR Database
mmu-miR-26b-3p	Rett syndrome	MNDR Database
mmu-miR-26b-3p	Seizures	MNDR Database

Interaction: ncRI-40926301

mmu-miR-26b-3p

⇔

Fbxl3