Interaction ID
ncRI-40926185
Interaction Molecules
mmu-miR-542-3p -- Trrap
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Mus musculus
Tissue or Cell Type
P19
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSMUSG00000045482
Description
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
| Pubmed ID | 29084942 | Journal | Nature communications |
|---|---|---|---|
| Title | Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq. | ||
| Author | Bottini S, Hamouda-Tekaya N, Mategot R, Zaragosi LE, Audebert S, Pisano S, Grandjean V, Mauduit C, Benahmed M, Barbry P, Repetto E, Trabucchi M | ||
| Molecule | Disease | Data Source |
|---|---|---|
| mmu-miR-542-3p | amyotrophic lateral sclerosis | MNDR Database |
| mmu-miR-542-3p | breast cancer | MNDR Database |
| mmu-miR-542-3p | Encephalomyelitis, Venezuelan Equine | MNDR Database |
| mmu-miR-542-3p | Epilepsia Partialis Continua | MNDR Database |
| mmu-miR-542-3p | Parkinson's disease | MNDR Database |
| mmu-miR-542-3p | Rett syndrome | MNDR Database |
| mmu-miR-542-3p | sensorineural hearing loss | MNDR Database |