Interaction ID
ncRI-40901486
Interaction Molecules
hsa-miR-2115-3p -- FRMD8
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
Left ventricle
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000126391
Description
Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019).
| Pubmed ID | 27418678 | Journal | Nucleic acids research |
|---|---|---|---|
| Title | Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP. | ||
| Author | Spengler RM, Zhang X, Cheng C, McLendon JM, Skeie JM, Johnson FL, Davidson BL, Boudreau RL | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-2115-3p | cancer | MNDR Database |
| hsa-miR-2115-3p | colon cancer | MNDR Database |
| hsa-miR-2115-3p | colorectal cancer | MNDR Database |
| hsa-miR-2115-3p | Down syndrome | MNDR Database |
| hsa-miR-2115-3p | stomach cancer | MNDR Database |