Interaction ID
ncRI-40897030
Interaction Molecules
mmu-miR-133b-3p -- Egfr
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
TargetScan with Ago CLIP data
Tags
Organism
Mus musculus
Tissue or Cell Type
Keratinocytes cell
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSMUSG00000020122
Description
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:8404850). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin- binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (By similarity). Plays a role in enhancing learning and memory performance (PubMed:20639532).
| Pubmed ID | 26203562 | Journal | eLife |
|---|---|---|---|
| Title | MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells. | ||
| Author | Riemondy K, Wang XJ, Torchia EC, Roop DR, Yi R | ||
| Molecule | Disease | Data Source |
|---|---|---|
| mmu-miR-133b-3p | acute disseminated encephalomyelitis | MNDR Database |
| mmu-miR-133b-3p | Alzheimer's disease | MNDR Database |
| mmu-miR-133b-3p | amyotrophic lateral sclerosis | MNDR Database |
| mmu-miR-133b-3p | cardiovascular system disease | MNDR Database |
| mmu-miR-133b-3p | encephalomyelitis | MNDR Database |
| mmu-miR-133b-3p | Encephalomyelitis, Autoimmune, Experimental | MNDR Database |
| mmu-miR-133b-3p | Epilepsia Partialis Continua | MNDR Database |
| mmu-miR-133b-3p | medulloblastoma | MNDR Database |
| mmu-miR-133b-3p | middle cerebral artery infarction | MNDR Database |
| mmu-miR-133b-3p | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| mmu-miR-133b-3p | Peripheral Nerve Injuries | MNDR Database |
| mmu-miR-133b-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| mmu-miR-133b-3p | Rett syndrome | MNDR Database |
| mmu-miR-133b-3p | Seizures | MNDR Database |
| mmu-miR-133b-3p | stomach cancer | MNDR Database |
| mmu-miR-133b-3p | West Nile fever | MNDR Database |