ncRI-40894987 - NPInter

Interaction Profile

Interaction ID

ncRI-40894987

Interaction Molecules

mmu-miR-214-3p -- Kptn

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

⇔

Kptn

Alias

Class

miRNA

miRBase id

MI0000698

Description

Mus musculus miR-214 stem-loop

Alias

Class

mRNA

Ensembl id

ENSMUSG00000006021

Description

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

Reference Information

Pubmed ID	26203562	Journal	eLife
Title	MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells.
Author	Riemondy K, Wang XJ, Torchia EC, Roop DR, Yi R

Network View

Disease Annotation

Molecule	Disease	Data Source
mmu-miR-214-3p	amyotrophic lateral sclerosis	MNDR Database
mmu-miR-214-3p	atherosclerosis	MNDR Database
mmu-miR-214-3p	cardiovascular system disease	MNDR Database
mmu-miR-214-3p	Chronic Pain	MNDR Database
mmu-miR-214-3p	Down syndrome	MNDR Database
mmu-miR-214-3p	Huntington's disease	MNDR Database
mmu-miR-214-3p	Meningitis, Escherichia coli	MNDR Database
mmu-miR-214-3p	Ophtalmological	MNDR Database
mmu-miR-214-3p	Parkinson's disease	MNDR Database
mmu-miR-214-3p	Peripheral Nerve Injuries	MNDR Database
mmu-miR-214-3p	Rett syndrome	MNDR Database
mmu-miR-214-3p	sickle cell anemia	MNDR Database
mmu-miR-214-3p	ulcerative colitis	MNDR Database
mmu-miR-214-3p	Wounds and Injuries	MNDR Database

Interaction: ncRI-40894987

mmu-miR-214-3p

⇔

Kptn