Interaction ID
ncRI-40894489
Interaction Molecules
mmu-miR-127-3p -- Hmgb2
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Mus musculus
Tissue or Cell Type
Keratinocytes cell
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSMUSG00000054717
Description
Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (PubMed:9184213). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (PubMed:19890330). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (By similarity). Has antimicrobial activity in gastrointestinal epithelial tissues (By similarity). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (PubMed:25306442). May play a role in germ cell differentiation (PubMed:11262228). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (PubMed:24391977). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (PubMed:19805379).
| Pubmed ID | 26203562 | Journal | eLife |
|---|---|---|---|
| Title | MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells. | ||
| Author | Riemondy K, Wang XJ, Torchia EC, Roop DR, Yi R | ||
| Molecule | Disease | Data Source |
|---|---|---|
| mmu-miR-127-3p | amyotrophic lateral sclerosis | MNDR Database |
| mmu-miR-127-3p | Epilepsia Partialis Continua | MNDR Database |
| mmu-miR-127-3p | fragile X syndrome | MNDR Database |
| mmu-miR-127-3p | Huntington's disease | MNDR Database |
| mmu-miR-127-3p | malignant glioma | MNDR Database |
| mmu-miR-127-3p | medulloblastoma | MNDR Database |
| mmu-miR-127-3p | middle cerebral artery infarction | MNDR Database |
| mmu-miR-127-3p | oligometastasis | MNDR Database |
| mmu-miR-127-3p | Peripheral Nerve Injuries | MNDR Database |
| mmu-miR-127-3p | Rett syndrome | MNDR Database |
| mmu-miR-127-3p | Sarcopenia | MNDR Database |
| mmu-miR-127-3p | Seizures | MNDR Database |
| mmu-miR-127-3p | sensorineural hearing loss | MNDR Database |
| mmu-miR-127-3p | Sleep Deprivation | MNDR Database |