Interaction ID
ncRI-40893986
Interaction Molecules
mmu-miR-141-3p -- Nedd4
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Mus musculus
Tissue or Cell Type
Keratinocytes cell
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSMUSG00000032216
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity). Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (By similarity).
| Pubmed ID | 26203562 | Journal | eLife |
|---|---|---|---|
| Title | MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells. | ||
| Author | Riemondy K, Wang XJ, Torchia EC, Roop DR, Yi R | ||
| Molecule | Disease | Data Source |
|---|---|---|
| mmu-miR-141-3p | acute disseminated encephalomyelitis | MNDR Database |
| mmu-miR-141-3p | Alzheimer's disease | MNDR Database |
| mmu-miR-141-3p | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| mmu-miR-141-3p | Down syndrome | MNDR Database |
| mmu-miR-141-3p | encephalomyelitis | MNDR Database |
| mmu-miR-141-3p | Encephalomyelitis, Autoimmune, Experimental | MNDR Database |
| mmu-miR-141-3p | Huntington's disease | MNDR Database |
| mmu-miR-141-3p | lung adenocarcinoma | MNDR Database |
| mmu-miR-141-3p | lung squamous cell carcinoma | MNDR Database |
| mmu-miR-141-3p | middle cerebral artery infarction | MNDR Database |
| mmu-miR-141-3p | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| mmu-miR-141-3p | Myocardial Reperfusion Injury | MNDR Database |
| mmu-miR-141-3p | pancreatic endocrine carcinoma | MNDR Database |
| mmu-miR-141-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| mmu-miR-141-3p | Seizures | MNDR Database |
| mmu-miR-141-3p | sensorineural hearing loss | MNDR Database |
| mmu-miR-141-3p | stomach cancer | MNDR Database |
| mmu-miR-141-3p | West Nile fever | MNDR Database |