Interaction ID

ncRI-40893033

Interaction Molecules

mmu-miR-484 -- Lats2

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Mus musculus

Tissue or Cell Type

Keratinocytes cell

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Alias

-

Class

miRNA

miRBase id

MI0003491

Description

Mus musculus miR-484 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSMUSG00000021959

Description

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (By similarity).