Interaction: ncRI-40892901

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Interaction Profile

Interaction ID

ncRI-40892901

Interaction Molecules

mmu-miR-17-3p -- Pkd1

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

TargetScan with Ago CLIP data

Tags

Organism

Mus musculus

Tissue or Cell Type

Keratinocytes cell

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset

Molecule Profile

mmu-miR-17-3p

⇔

Pkd1

Alias

-

Class

miRNA

miRBase id

MI0000687

Description

Mus musculus miR-17 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSMUSG00000032855

Description

Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity (By similarity). Involved in renal tubulogenesis (PubMed:24939912). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735). Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein- protein and protein-carbohydrate.

Reference Information
Pubmed ID 26203562 Journal eLife
Title MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells.
Author Riemondy K, Wang XJ, Torchia EC, Roop DR, Yi R
Network View
Disease Annotation
Molecule Disease Data Source
mmu-miR-17-3p acute disseminated encephalomyelitis MNDR Database
mmu-miR-17-3p amyotrophic lateral sclerosis MNDR Database
mmu-miR-17-3p Arrhythmias, Cardiac MNDR Database
mmu-miR-17-3p B-cell lymphoma MNDR Database
mmu-miR-17-3p breast cancer MNDR Database
mmu-miR-17-3p Cardiomegaly MNDR Database
mmu-miR-17-3p cardiomyopathy MNDR Database
mmu-miR-17-3p Chronic Pain MNDR Database
mmu-miR-17-3p colorectal cancer MNDR Database
mmu-miR-17-3p congenital myopathy MNDR Database
mmu-miR-17-3p encephalomyelitis MNDR Database
mmu-miR-17-3p Encephalomyelitis, Autoimmune, Experimental MNDR Database
mmu-miR-17-3p Epilepsia Partialis Continua MNDR Database
mmu-miR-17-3p Graft vs Host Disease MNDR Database
mmu-miR-17-3p Heart Failure MNDR Database
mmu-miR-17-3p Lesch-Nyhan syndrome MNDR Database
mmu-miR-17-3p medulloblastoma MNDR Database
mmu-miR-17-3p Meningitis, Escherichia coli MNDR Database
mmu-miR-17-3p Multiple Sclerosis, Chronic Progressive MNDR Database
mmu-miR-17-3p Myotonic Dystrophy MNDR Database
mmu-miR-17-3p Non-alcoholic Fatty Liver Disease MNDR Database
mmu-miR-17-3p osteoporosis MNDR Database
mmu-miR-17-3p Peripheral Nerve Injuries MNDR Database
mmu-miR-17-3p relapsing-remitting multiple sclerosis MNDR Database
mmu-miR-17-3p Retinal Vessels MNDR Database
mmu-miR-17-3p Rett syndrome MNDR Database
mmu-miR-17-3p sensorineural hearing loss MNDR Database
mmu-miR-17-3p Spinal Cord Injuries MNDR Database