Interaction ID
ncRI-40892826
Interaction Molecules
mmu-miR-665-3p -- Chchd4
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Mus musculus
Tissue or Cell Type
Keratinocytes cell
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSMUSG00000034203
Description
Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19 and MICU1. Required for the import and folding of small cysteine- containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake.
| Pubmed ID | 26203562 | Journal | eLife |
|---|---|---|---|
| Title | MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells. | ||
| Author | Riemondy K, Wang XJ, Torchia EC, Roop DR, Yi R | ||
| Molecule | Disease | Data Source |
|---|---|---|
| mmu-miR-665-3p | amyotrophic lateral sclerosis | MNDR Database |
| mmu-miR-665-3p | bronchiolitis obliterans | MNDR Database |
| mmu-miR-665-3p | middle cerebral artery infarction | MNDR Database |
| mmu-miR-665-3p | Rett syndrome | MNDR Database |