Interaction ID
ncRI-40892821
Interaction Molecules
mmu-miR-25-3p -- Nlk
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
TargetScan with Ago CLIP data
Tags
Organism
Mus musculus
Tissue or Cell Type
Keratinocytes cell
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSMUSG00000017376
Description
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (By similarity).
| Pubmed ID | 26203562 | Journal | eLife |
|---|---|---|---|
| Title | MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells. | ||
| Author | Riemondy K, Wang XJ, Torchia EC, Roop DR, Yi R | ||
| Molecule | Disease | Data Source |
|---|---|---|
| mmu-miR-25-3p | acute disseminated encephalomyelitis | MNDR Database |
| mmu-miR-25-3p | amyotrophic lateral sclerosis | MNDR Database |
| mmu-miR-25-3p | Arrhythmias, Cardiac | MNDR Database |
| mmu-miR-25-3p | atrial fibrillation | MNDR Database |
| mmu-miR-25-3p | Brain Injury, Chronic | MNDR Database |
| mmu-miR-25-3p | Cardiomegaly | MNDR Database |
| mmu-miR-25-3p | cardiomyopathy | MNDR Database |
| mmu-miR-25-3p | cardiovascular system disease | MNDR Database |
| mmu-miR-25-3p | encephalomyelitis | MNDR Database |
| mmu-miR-25-3p | Encephalomyelitis, Autoimmune, Experimental | MNDR Database |
| mmu-miR-25-3p | esophagus squamous cell carcinoma | MNDR Database |
| mmu-miR-25-3p | Hearing Loss, Bilateral | MNDR Database |
| mmu-miR-25-3p | Heart Failure | MNDR Database |
| mmu-miR-25-3p | Hyperalgesia | MNDR Database |
| mmu-miR-25-3p | medulloblastoma | MNDR Database |
| mmu-miR-25-3p | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| mmu-miR-25-3p | Parkinson's disease | MNDR Database |
| mmu-miR-25-3p | Peripheral Nerve Injuries | MNDR Database |
| mmu-miR-25-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| mmu-miR-25-3p | Rett syndrome | MNDR Database |
| mmu-miR-25-3p | sensorineural hearing loss | MNDR Database |
| mmu-miR-25-3p | Thyroid Carcinoma, Anaplastic | MNDR Database |