Interaction Profile
Interaction ID
ncRI-40835001
Interaction Molecules
hsa-miR-4282 -- GAB1
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
motor cortex
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Molecule Profile
Alias
-
Class
mRNA
Ensembl id
ENSG00000109458
Description
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).
Reference Information
| Pubmed ID | 24389009 | Journal | Neuron |
|---|---|---|---|
| Title | Transcriptome-wide discovery of microRNA binding sites in human brain. | ||
| Author | Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL | ||
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-4282 | brain disease | MNDR Database |
| hsa-miR-4282 | breast cancer | MNDR Database |
| hsa-miR-4282 | cancer | MNDR Database |
| hsa-miR-4282 | carcinoma | MNDR Database |
| hsa-miR-4282 | colorectal cancer | MNDR Database |
| hsa-miR-4282 | Colorectal Neoplasms | MNDR Database |
| hsa-miR-4282 | eye disease | MNDR Database |
| hsa-miR-4282 | intellectual disability | MNDR Database |
| hsa-miR-4282 | leukemia | MNDR Database |
| hsa-miR-4282 | neurodegenerative disease | MNDR Database |
| hsa-miR-4282 | pancreatic cancer | MNDR Database |
| hsa-miR-4282 | schizophrenia | MNDR Database |
| hsa-miR-4282 | stomach cancer | MNDR Database |
| hsa-miR-4282 | vascular disease | MNDR Database |