Interaction: ncRI-40823142

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Interaction Profile

Interaction ID

ncRI-40823142

Interaction Molecules

hsa-miR-302a-3p -- STK4

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

Cingulategyrus

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-302a-3p

⇔

STK4

Alias

-

Class

miRNA

miRBase id

MI0000738

Description

Homo sapiens miR-302a stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000101109

Description

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

Reference Information
Pubmed ID 24389009 Journal Neuron
Title Transcriptome-wide discovery of microRNA binding sites in human brain.
Author Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-302a-3p acute pancreatitis MNDR Database
hsa-miR-302a-3p allergic contact dermatitis MNDR Database
hsa-miR-302a-3p allergic hypersensitivity disease MNDR Database
hsa-miR-302a-3p allergic rhinitis MNDR Database
hsa-miR-302a-3p Alzheimer's disease MNDR Database
hsa-miR-302a-3p amyotrophic lateral sclerosis MNDR Database
hsa-miR-302a-3p arthritis MNDR Database
hsa-miR-302a-3p aspiration pneumonia MNDR Database
hsa-miR-302a-3p asthma MNDR Database
hsa-miR-302a-3p atopic dermatitis MNDR Database
hsa-miR-302a-3p azoospermia MNDR Database
hsa-miR-302a-3p B-cell lymphoma MNDR Database
hsa-miR-302a-3p bone disease MNDR Database
hsa-miR-302a-3p brain disease MNDR Database
hsa-miR-302a-3p breast cancer MNDR Database
hsa-miR-302a-3p Breast Neoplasms MNDR Database
hsa-miR-302a-3p bronchitis MNDR Database
hsa-miR-302a-3p Burkitt lymphoma MNDR Database
hsa-miR-302a-3p cancer MNDR Database
hsa-miR-302a-3p carcinoma MNDR Database
hsa-miR-302a-3p cholera MNDR Database
hsa-miR-302a-3p chronic interstitial cystitis MNDR Database
hsa-miR-302a-3p colon cancer MNDR Database
hsa-miR-302a-3p colorectal adenoma MNDR Database
hsa-miR-302a-3p colorectal cancer MNDR Database
hsa-miR-302a-3p complex regional pain syndrome MNDR Database
hsa-miR-302a-3p constipation MNDR Database
hsa-miR-302a-3p contact dermatitis MNDR Database
hsa-miR-302a-3p cystitis MNDR Database
hsa-miR-302a-3p dermatitis MNDR Database
hsa-miR-302a-3p diabetes mellitus MNDR Database
hsa-miR-302a-3p diabetic neuropathy MNDR Database
hsa-miR-302a-3p diarrhea MNDR Database
hsa-miR-302a-3p dilated cardiomyopathy MNDR Database
hsa-miR-302a-3p epicondylitis MNDR Database
hsa-miR-302a-3p esophageal cancer MNDR Database
hsa-miR-302a-3p eye disease MNDR Database
hsa-miR-302a-3p familiar ovarian carcinoma MNDR Database
hsa-miR-302a-3p Fatty Liver MNDR Database
hsa-miR-302a-3p fibromyalgia MNDR Database
hsa-miR-302a-3p gastric lymphoma MNDR Database
hsa-miR-302a-3p Glioblastoma MNDR Database
hsa-miR-302a-3p head and neck cancer MNDR Database
hsa-miR-302a-3p heart disease MNDR Database
hsa-miR-302a-3p Heart Failure MNDR Database
hsa-miR-302a-3p hepatocellular carcinoma MNDR Database
hsa-miR-302a-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-302a-3p Hirschsprung's disease MNDR Database
hsa-miR-302a-3p Hodgkin's lymphoma MNDR Database
hsa-miR-302a-3p Huntington's disease MNDR Database
hsa-miR-302a-3p hypertension MNDR Database
hsa-miR-302a-3p inflammatory bowel disease MNDR Database
hsa-miR-302a-3p intellectual disability MNDR Database
hsa-miR-302a-3p interstitial cystitis MNDR Database
hsa-miR-302a-3p intestinal disease MNDR Database
hsa-miR-302a-3p irritable bowel syndrome MNDR Database
hsa-miR-302a-3p keratopathy MNDR Database
hsa-miR-302a-3p leukemia MNDR Database
hsa-miR-302a-3p lung cancer MNDR Database
hsa-miR-302a-3p lung disease MNDR Database
hsa-miR-302a-3p Lymphoblastoid MNDR Database
hsa-miR-302a-3p lymphoma MNDR Database
hsa-miR-302a-3p Lymphoma, Non-Hodgkin MNDR Database
hsa-miR-302a-3p malignant glioma MNDR Database
hsa-miR-302a-3p megacolon MNDR Database
hsa-miR-302a-3p melanoma MNDR Database
hsa-miR-302a-3p migraine MNDR Database
hsa-miR-302a-3p motion sickness MNDR Database
hsa-miR-302a-3p multiple chemical sensitivity MNDR Database
hsa-miR-302a-3p multiple myeloma MNDR Database
hsa-miR-302a-3p multiple system atrophy MNDR Database
hsa-miR-302a-3p myofascial pain syndrome MNDR Database
hsa-miR-302a-3p myopathy MNDR Database
hsa-miR-302a-3p myositis MNDR Database
hsa-miR-302a-3p Neoplasms MNDR Database
hsa-miR-302a-3p nephroblastoma MNDR Database
hsa-miR-302a-3p neurodegenerative disease MNDR Database
hsa-miR-302a-3p oral squamous cell carcinoma MNDR Database
hsa-miR-302a-3p osteoarthritis MNDR Database
hsa-miR-302a-3p Ovarian Neoplasms MNDR Database
hsa-miR-302a-3p pain agnosia MNDR Database
hsa-miR-302a-3p pain disorder MNDR Database
hsa-miR-302a-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-302a-3p pancreatic cancer MNDR Database
hsa-miR-302a-3p pancreatitis MNDR Database
hsa-miR-302a-3p Parkinson's disease MNDR Database
hsa-miR-302a-3p peripheral nervous system disease MNDR Database
hsa-miR-302a-3p peripheral vascular disease MNDR Database
hsa-miR-302a-3p Peripheral Nervous System Diseases MNDR Database
hsa-miR-302a-3p Precursor Cell Lymphoblastic Leukemia-Lymphoma MNDR Database
hsa-miR-302a-3p pre-eclampsia MNDR Database
hsa-miR-302a-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-302a-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-302a-3p Prostatic Neoplasms MNDR Database
hsa-miR-302a-3p psoriasis MNDR Database
hsa-miR-302a-3p pulmonary tuberculosis MNDR Database
hsa-miR-302a-3p retinoblastoma MNDR Database
hsa-miR-302a-3p rheumatoid arthritis MNDR Database
hsa-miR-302a-3p rhinitis MNDR Database
hsa-miR-302a-3p schistosomiasis MNDR Database
hsa-miR-302a-3p sensory peripheral neuropathy MNDR Database
hsa-miR-302a-3p skin cancer MNDR Database
hsa-miR-302a-3p skin disease MNDR Database
hsa-miR-302a-3p squamous cell carcinoma MNDR Database
hsa-miR-302a-3p stomach cancer MNDR Database
hsa-miR-302a-3p striatonigral degeneration MNDR Database
hsa-miR-302a-3p Subarachnoid Hemorrhage, Traumatic MNDR Database
hsa-miR-302a-3p sudden infant death syndrome MNDR Database
hsa-miR-302a-3p syndrome MNDR Database
hsa-miR-302a-3p T-cell leukemia MNDR Database
hsa-miR-302a-3p teratocarcinoma MNDR Database
hsa-miR-302a-3p tonsil cancer MNDR Database
hsa-miR-302a-3p trigeminal neuralgia MNDR Database
hsa-miR-302a-3p ulcerative colitis MNDR Database
hsa-miR-302a-3p urticaria MNDR Database
hsa-miR-302a-3p uterine cancer MNDR Database
hsa-miR-302a-3p Uterine Cervical Neoplasms MNDR Database
hsa-miR-302a-3p vascular disease MNDR Database
hsa-miR-302a-3p t-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations eDGAR Database