Interaction ID
ncRI-40814495
Interaction Molecules
hsa-miR-1203 -- EIF4A2
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
Cingulategyrus;Left ventricle;tumor;motor cortex
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000156976
Description
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
| Pubmed ID | 24389009 | Journal | Neuron |
|---|---|---|---|
| Title | Transcriptome-wide discovery of microRNA binding sites in human brain. | ||
| Author | Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL | ||
| Pubmed ID | 27418678 | Journal | Nucleic acids research |
|---|---|---|---|
| Title | Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP. | ||
| Author | Spengler RM, Zhang X, Cheng C, McLendon JM, Skeie JM, Johnson FL, Davidson BL, Boudreau RL | ||
| Pubmed ID | 28735896 | Journal | Molecular cell |
|---|---|---|---|
| Title | Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. | ||
| Author | Luna JM, Barajas JM, Teng KY, Sun HL, Moore MJ, Rice CM, Darnell RB, Ghoshal K | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-1203 | biliary tract cancer | MNDR Database |
| hsa-miR-1203 | colorectal cancer | MNDR Database |
| hsa-miR-1203 | esophagus small cell carcinoma | MNDR Database |
| hsa-miR-1203 | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-1203 | Glioblastoma | MNDR Database |
| hsa-miR-1203 | hepatocellular carcinoma | MNDR Database |
| hsa-miR-1203 | nasopharynx carcinoma | MNDR Database |
| hsa-miR-1203 | pancreatic cancer | MNDR Database |
| hsa-miR-1203 | stomach cancer | MNDR Database |