Interaction Profile
Interaction ID
ncRI-40789943
Interaction Molecules
hsa-miR-20b-3p -- ZNF207
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
Cingulategyrus
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Molecule Profile
Alias
-
Class
mRNA
Ensembl id
ENSG00000010244
Description
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
Reference Information
| Pubmed ID | 24389009 | Journal | Neuron |
|---|---|---|---|
| Title | Transcriptome-wide discovery of microRNA binding sites in human brain. | ||
| Author | Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL | ||
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-20b-3p | acute T cell leukemia | MNDR Database |
| hsa-miR-20b-3p | Adrenocortical Carcinoma | MNDR Database |
| hsa-miR-20b-3p | Alzheimer's disease | MNDR Database |
| hsa-miR-20b-3p | amyotrophic lateral sclerosis | MNDR Database |
| hsa-miR-20b-3p | astrocytoma | MNDR Database |
| hsa-miR-20b-3p | autosomal recessive disease | MNDR Database |
| hsa-miR-20b-3p | autosomal recessive limb-girdle muscular dystrophy type 2A | MNDR Database |
| hsa-miR-20b-3p | autosomal recessive limb-girdle muscular dystrophy type 2B | MNDR Database |
| hsa-miR-20b-3p | Barrett's adenocarcinoma | MNDR Database |
| hsa-miR-20b-3p | B-cell lymphoma | MNDR Database |
| hsa-miR-20b-3p | biliary tract cancer | MNDR Database |
| hsa-miR-20b-3p | bone disease | MNDR Database |
| hsa-miR-20b-3p | brain disease | MNDR Database |
| hsa-miR-20b-3p | breast cancer | MNDR Database |
| hsa-miR-20b-3p | Breast Neoplasms | MNDR Database |
| hsa-miR-20b-3p | cancer | MNDR Database |
| hsa-miR-20b-3p | carcinoma | MNDR Database |
| hsa-miR-20b-3p | Carcinoma, Ductal, Breast | MNDR Database |
| hsa-miR-20b-3p | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| hsa-miR-20b-3p | Carcinoma, Renal Cell | MNDR Database |
| hsa-miR-20b-3p | central nervous system lymphoma | MNDR Database |
| hsa-miR-20b-3p | cervical adenocarcinoma | MNDR Database |
| hsa-miR-20b-3p | cervical squamous cell carcinoma | MNDR Database |
| hsa-miR-20b-3p | cholangiocarcinoma | MNDR Database |
| hsa-miR-20b-3p | colon cancer | MNDR Database |
| hsa-miR-20b-3p | colorectal cancer | MNDR Database |
| hsa-miR-20b-3p | dermatomyositis | MNDR Database |
| hsa-miR-20b-3p | diabetes mellitus | MNDR Database |
| hsa-miR-20b-3p | dilated cardiomyopathy | MNDR Database |
| hsa-miR-20b-3p | Ependymoma | MNDR Database |
| hsa-miR-20b-3p | esophageal cancer | MNDR Database |
| hsa-miR-20b-3p | esophageal carcinoma | MNDR Database |
| hsa-miR-20b-3p | eye disease | MNDR Database |
| hsa-miR-20b-3p | Friedreich ataxia | MNDR Database |
| hsa-miR-20b-3p | Gait Ataxia | MNDR Database |
| hsa-miR-20b-3p | gastric adenocarcinoma | MNDR Database |
| hsa-miR-20b-3p | Glioblastoma | MNDR Database |
| hsa-miR-20b-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-20b-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-20b-3p | Hodgkin's lymphoma | MNDR Database |
| hsa-miR-20b-3p | intellectual disability | MNDR Database |
| hsa-miR-20b-3p | interstitial lung disease | MNDR Database |
| hsa-miR-20b-3p | intracranial aneurysm | MNDR Database |
| hsa-miR-20b-3p | kidney cancer | MNDR Database |
| hsa-miR-20b-3p | kidney disease | MNDR Database |
| hsa-miR-20b-3p | large cell neuroendocrine cancer | MNDR Database |
| hsa-miR-20b-3p | Laryngeal Neoplasms | MNDR Database |
| hsa-miR-20b-3p | leukemia | MNDR Database |
| hsa-miR-20b-3p | liposarcoma | MNDR Database |
| hsa-miR-20b-3p | Liver Neoplasms | MNDR Database |
| hsa-miR-20b-3p | lung adenocarcinoma | MNDR Database |
| hsa-miR-20b-3p | lung cancer | MNDR Database |
| hsa-miR-20b-3p | lung disease | MNDR Database |
| hsa-miR-20b-3p | lung small cell carcinoma | MNDR Database |
| hsa-miR-20b-3p | lung squamous cell carcinoma | MNDR Database |
| hsa-miR-20b-3p | lymphoma | MNDR Database |
| hsa-miR-20b-3p | malignant glioma | MNDR Database |
| hsa-miR-20b-3p | malignant pleural mesothelioma | MNDR Database |
| hsa-miR-20b-3p | mantle cell lymphoma | MNDR Database |
| hsa-miR-20b-3p | medulloblastoma | MNDR Database |
| hsa-miR-20b-3p | melanoma | MNDR Database |
| hsa-miR-20b-3p | Mesothelioma | MNDR Database |
| hsa-miR-20b-3p | multiple myeloma | MNDR Database |
| hsa-miR-20b-3p | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| hsa-miR-20b-3p | muscular disease | MNDR Database |
| hsa-miR-20b-3p | myasthenia gravis | MNDR Database |
| hsa-miR-20b-3p | Myasthenia Gravis, Autoimmune, Experimental | MNDR Database |
| hsa-miR-20b-3p | nasopharynx carcinoma | MNDR Database |
| hsa-miR-20b-3p | nemaline myopathy | MNDR Database |
| hsa-miR-20b-3p | Neoplasms | MNDR Database |
| hsa-miR-20b-3p | nephroblastoma | MNDR Database |
| hsa-miR-20b-3p | neuroblastoma | MNDR Database |
| hsa-miR-20b-3p | neurodegenerative disease | MNDR Database |
| hsa-miR-20b-3p | oral squamous cell carcinoma | MNDR Database |
| hsa-miR-20b-3p | osteosarcoma | MNDR Database |
| hsa-miR-20b-3p | ovarian carcinoma | MNDR Database |
| hsa-miR-20b-3p | Ovarian Neoplasms | MNDR Database |
| hsa-miR-20b-3p | pancreatic cancer | MNDR Database |
| hsa-miR-20b-3p | papillary renal cell carcinoma | MNDR Database |
| hsa-miR-20b-3p | pre-eclampsia | MNDR Database |
| hsa-miR-20b-3p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-20b-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-20b-3p | prostate adenocarcinoma | MNDR Database |
| hsa-miR-20b-3p | Prostatic Neoplasms | MNDR Database |
| hsa-miR-20b-3p | Pseudorabies | MNDR Database |
| hsa-miR-20b-3p | rectum adenocarcinoma | MNDR Database |
| hsa-miR-20b-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-20b-3p | renal cell carcinoma | MNDR Database |
| hsa-miR-20b-3p | renal clear cell carcinoma | MNDR Database |
| hsa-miR-20b-3p | retinal degeneration | MNDR Database |
| hsa-miR-20b-3p | salivary gland cancer | MNDR Database |
| hsa-miR-20b-3p | schizophrenia | MNDR Database |
| hsa-miR-20b-3p | squamous cell carcinoma | MNDR Database |
| hsa-miR-20b-3p | stomach cancer | MNDR Database |
| hsa-miR-20b-3p | Stroke, Lacunar | MNDR Database |
| hsa-miR-20b-3p | Subarachnoid Hemorrhage, Traumatic | MNDR Database |
| hsa-miR-20b-3p | synovial sarcoma | MNDR Database |
| hsa-miR-20b-3p | T-cell leukemia | MNDR Database |
| hsa-miR-20b-3p | testicular germ cell cancer | MNDR Database |
| hsa-miR-20b-3p | thyroid cancer | MNDR Database |
| hsa-miR-20b-3p | thyroid carcinoma | MNDR Database |
| hsa-miR-20b-3p | toxoplasmosis | MNDR Database |
| hsa-miR-20b-3p | type 2 diabetes mellitus | MNDR Database |
| hsa-miR-20b-3p | urinary bladder cancer | MNDR Database |
| hsa-miR-20b-3p | uterine corpus endometrial carcinoma | MNDR Database |
| hsa-miR-20b-3p | Uterine Cervical Neoplasms | MNDR Database |
| hsa-miR-20b-3p | vascular disease | MNDR Database |