Interaction: ncRI-40685453

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Interaction Profile

Interaction ID

ncRI-40685453

Interaction Molecules

hsa-miR-106a-3p -- ATP8A1

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T;motor cortex

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-106a-3p

⇔

ATP8A1

Alias

-

Class

miRNA

miRBase id

MI0000113

Description

Homo sapiens miR-106a stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000124406

Description

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.

Reference Information
Pubmed ID 24389009 Journal Neuron
Title Transcriptome-wide discovery of microRNA binding sites in human brain.
Author Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-106a-3p acute myeloid leukemia MNDR Database
hsa-miR-106a-3p acute T cell leukemia MNDR Database
hsa-miR-106a-3p adenocarcinoma MNDR Database
hsa-miR-106a-3p adenoma MNDR Database
hsa-miR-106a-3p Alzheimer's disease MNDR Database
hsa-miR-106a-3p amyotrophic lateral sclerosis MNDR Database
hsa-miR-106a-3p aortic valve disease MNDR Database
hsa-miR-106a-3p Arsenic Poisoning MNDR Database
hsa-miR-106a-3p astrocytoma MNDR Database
hsa-miR-106a-3p autism spectrum disorder MNDR Database
hsa-miR-106a-3p autosomal recessive limb-girdle muscular dystrophy type 2A MNDR Database
hsa-miR-106a-3p autosomal recessive limb-girdle muscular dystrophy type 2B MNDR Database
hsa-miR-106a-3p B-cell lymphoma MNDR Database
hsa-miR-106a-3p biliary tract cancer MNDR Database
hsa-miR-106a-3p bladder urothelial carcinoma MNDR Database
hsa-miR-106a-3p bone disease MNDR Database
hsa-miR-106a-3p brain disease MNDR Database
hsa-miR-106a-3p breast cancer MNDR Database
hsa-miR-106a-3p Breast Neoplasms MNDR Database
hsa-miR-106a-3p Burkitt lymphoma MNDR Database
hsa-miR-106a-3p cancer MNDR Database
hsa-miR-106a-3p carcinoma MNDR Database
hsa-miR-106a-3p Carcinoma, Ductal, Breast MNDR Database
hsa-miR-106a-3p Carcinoma, Non-Small-Cell Lung MNDR Database
hsa-miR-106a-3p Carcinoma, Renal Cell MNDR Database
hsa-miR-106a-3p cervical adenocarcinoma MNDR Database
hsa-miR-106a-3p cervical squamous cell carcinoma MNDR Database
hsa-miR-106a-3p cholangiocarcinoma MNDR Database
hsa-miR-106a-3p chronic fatigue syndrome MNDR Database
hsa-miR-106a-3p chronic lymphocytic leukemia MNDR Database
hsa-miR-106a-3p chronic myeloid leukemia MNDR Database
hsa-miR-106a-3p colon adenocarcinoma MNDR Database
hsa-miR-106a-3p colon cancer MNDR Database
hsa-miR-106a-3p colorectal cancer MNDR Database
hsa-miR-106a-3p Crohn's disease MNDR Database
hsa-miR-106a-3p diabetes mellitus MNDR Database
hsa-miR-106a-3p diffuse large B-cell lymphoma MNDR Database
hsa-miR-106a-3p dilated cardiomyopathy MNDR Database
hsa-miR-106a-3p Down syndrome MNDR Database
hsa-miR-106a-3p Duke C MNDR Database
hsa-miR-106a-3p embryonal cancer MNDR Database
hsa-miR-106a-3p endometrial cancer MNDR Database
hsa-miR-106a-3p Ependymoma MNDR Database
hsa-miR-106a-3p esophageal cancer MNDR Database
hsa-miR-106a-3p eye disease MNDR Database
hsa-miR-106a-3p familiar ovarian carcinoma MNDR Database
hsa-miR-106a-3p Fatty Liver MNDR Database
hsa-miR-106a-3p follicular lymphoma MNDR Database
hsa-miR-106a-3p fragile X syndrome MNDR Database
hsa-miR-106a-3p gastric adenocarcinoma MNDR Database
hsa-miR-106a-3p gastric lymphoma MNDR Database
hsa-miR-106a-3p Glioblastoma MNDR Database
hsa-miR-106a-3p head and neck cancer MNDR Database
hsa-miR-106a-3p head and neck squamous cell carcinoma MNDR Database
hsa-miR-106a-3p Heart Failure MNDR Database
hsa-miR-106a-3p hepatitis B MNDR Database
hsa-miR-106a-3p Hepatitis, Viral, Human MNDR Database
hsa-miR-106a-3p hepatocellular carcinoma MNDR Database
hsa-miR-106a-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-106a-3p Hodgkin's lymphoma MNDR Database
hsa-miR-106a-3p Huntington's disease MNDR Database
hsa-miR-106a-3p hypersensitivity reaction type II disease MNDR Database
hsa-miR-106a-3p Hypersomnolence, Idiopathic MNDR Database
hsa-miR-106a-3p inflammatory bowel disease MNDR Database
hsa-miR-106a-3p intellectual disability MNDR Database
hsa-miR-106a-3p kidney cancer MNDR Database
hsa-miR-106a-3p Lesch-Nyhan syndrome MNDR Database
hsa-miR-106a-3p leukemia MNDR Database
hsa-miR-106a-3p Lewy body dementia MNDR Database
hsa-miR-106a-3p liposarcoma MNDR Database
hsa-miR-106a-3p Liver Neoplasms MNDR Database
hsa-miR-106a-3p lung adenocarcinoma MNDR Database
hsa-miR-106a-3p lung cancer MNDR Database
hsa-miR-106a-3p lung small cell carcinoma MNDR Database
hsa-miR-106a-3p lung squamous cell carcinoma MNDR Database
hsa-miR-106a-3p Lymphoblastoid MNDR Database
hsa-miR-106a-3p lymphoma MNDR Database
hsa-miR-106a-3p Lymphoma, Follicular MNDR Database
hsa-miR-106a-3p Lymphoma, Non-Hodgkin MNDR Database
hsa-miR-106a-3p malignant glioma MNDR Database
hsa-miR-106a-3p medulloblastoma MNDR Database
hsa-miR-106a-3p melanoma MNDR Database
hsa-miR-106a-3p meningioma MNDR Database
hsa-miR-106a-3p Mesothelioma MNDR Database
hsa-miR-106a-3p multiple myeloma MNDR Database
hsa-miR-106a-3p multiple sclerosis MNDR Database
hsa-miR-106a-3p Multiple Sclerosis, Chronic Progressive MNDR Database
hsa-miR-106a-3p muscular disease MNDR Database
hsa-miR-106a-3p myelodysplastic/myeloproliferative neoplasm MNDR Database
hsa-miR-106a-3p nasopharynx carcinoma MNDR Database
hsa-miR-106a-3p nemaline myopathy MNDR Database
hsa-miR-106a-3p Neoplasms MNDR Database
hsa-miR-106a-3p nephroblastoma MNDR Database
hsa-miR-106a-3p neuroblastoma MNDR Database
hsa-miR-106a-3p neurodegenerative disease MNDR Database
hsa-miR-106a-3p oral squamous cell carcinoma MNDR Database
hsa-miR-106a-3p osteosarcoma MNDR Database
hsa-miR-106a-3p ovarian carcinoma MNDR Database
hsa-miR-106a-3p ovarian clear cell carcinoma MNDR Database
hsa-miR-106a-3p Ovarian Neoplasms MNDR Database
hsa-miR-106a-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-106a-3p pancreatic cancer MNDR Database
hsa-miR-106a-3p papillary renal cell carcinoma MNDR Database
hsa-miR-106a-3p papillary thyroid carcinoma MNDR Database
hsa-miR-106a-3p Parkinson's disease MNDR Database
hsa-miR-106a-3p Precursor Cell Lymphoblastic Leukemia-Lymphoma MNDR Database
hsa-miR-106a-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-106a-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-106a-3p prostate adenocarcinoma MNDR Database
hsa-miR-106a-3p Prostatic Neoplasms MNDR Database
hsa-miR-106a-3p Pseudorabies MNDR Database
hsa-miR-106a-3p psoriasis MNDR Database
hsa-miR-106a-3p rectum adenocarcinoma MNDR Database
hsa-miR-106a-3p relapsing-remitting multiple sclerosis MNDR Database
hsa-miR-106a-3p renal cell carcinoma MNDR Database
hsa-miR-106a-3p renal clear cell carcinoma MNDR Database
hsa-miR-106a-3p Retinal Neovascularization MNDR Database
hsa-miR-106a-3p rhabdomyosarcoma MNDR Database
hsa-miR-106a-3p Sepsis MNDR Database
hsa-miR-106a-3p small intestine cancer MNDR Database
hsa-miR-106a-3p squamous cell carcinoma MNDR Database
hsa-miR-106a-3p stomach cancer MNDR Database
hsa-miR-106a-3p Stroke, Lacunar MNDR Database
hsa-miR-106a-3p syndrome MNDR Database
hsa-miR-106a-3p T-cell leukemia MNDR Database
hsa-miR-106a-3p temporal lobe epilepsy MNDR Database
hsa-miR-106a-3p testicular germ cell cancer MNDR Database
hsa-miR-106a-3p thyroid cancer MNDR Database
hsa-miR-106a-3p thyroid carcinoma MNDR Database
hsa-miR-106a-3p Toxoplasma MNDR Database
hsa-miR-106a-3p toxoplasmosis MNDR Database
hsa-miR-106a-3p Urinary Bladder Neoplasms MNDR Database
hsa-miR-106a-3p uterine corpus endometrial carcinoma MNDR Database
hsa-miR-106a-3p Uterine Cervical Neoplasms MNDR Database
hsa-miR-106a-3p vascular disease MNDR Database