Interaction Profile
Interaction ID
ncRI-40669040
Interaction Molecules
hsa-miR-875-3p -- UBN1
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293T;T-REx-293T;HEK293S
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Molecule Profile
Alias
-
Class
mRNA
Ensembl id
ENSG00000118900
Description
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly.
Reference Information
| Pubmed ID | 23824327 | Journal | Genes & development |
|---|---|---|---|
| Title | Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. | ||
| Author | Karginov FV, Hannon GJ | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-875-3p | autosomal recessive disease | MNDR Database |
| hsa-miR-875-3p | bone disease | MNDR Database |
| hsa-miR-875-3p | brain disease | MNDR Database |
| hsa-miR-875-3p | breast cancer | MNDR Database |
| hsa-miR-875-3p | Breast Neoplasms | MNDR Database |
| hsa-miR-875-3p | cancer | MNDR Database |
| hsa-miR-875-3p | carcinoma | MNDR Database |
| hsa-miR-875-3p | cholangiocarcinoma | MNDR Database |
| hsa-miR-875-3p | colorectal cancer | MNDR Database |
| hsa-miR-875-3p | diabetes mellitus | MNDR Database |
| hsa-miR-875-3p | eye disease | MNDR Database |
| hsa-miR-875-3p | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-875-3p | heart disease | MNDR Database |
| hsa-miR-875-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-875-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-875-3p | hypersensitivity reaction type II disease | MNDR Database |
| hsa-miR-875-3p | kidney disease | MNDR Database |
| hsa-miR-875-3p | leukemia | MNDR Database |
| hsa-miR-875-3p | lung adenocarcinoma | MNDR Database |
| hsa-miR-875-3p | lung cancer | MNDR Database |
| hsa-miR-875-3p | lung disease | MNDR Database |
| hsa-miR-875-3p | lymphoma | MNDR Database |
| hsa-miR-875-3p | medulloblastoma | MNDR Database |
| hsa-miR-875-3p | melanoma | MNDR Database |
| hsa-miR-875-3p | nasopharynx carcinoma | MNDR Database |
| hsa-miR-875-3p | neurodegenerative disease | MNDR Database |
| hsa-miR-875-3p | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-875-3p | pancreatic cancer | MNDR Database |
| hsa-miR-875-3p | pancreatic ductal adenocarcinoma | MNDR Database |
| hsa-miR-875-3p | Papillomaviridae | MNDR Database |
| hsa-miR-875-3p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-875-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-875-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-875-3p | stomach cancer | MNDR Database |
| hsa-miR-875-3p | stomach carcinoma | MNDR Database |
| hsa-miR-875-3p | vascular disease | MNDR Database |
| hsa-miR-875-3p | hydrops fetalis, nonimmune | eDGAR Database |