Interaction ID
ncRI-40663395
Interaction Molecules
hsa-miR-1260b -- STUB1
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000103266
Description
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin- mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Likely mediates polyubiquitination and downregulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609).
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-1260b | biliary tract cancer | MNDR Database |
| hsa-miR-1260b | brain stem cancer | MNDR Database |
| hsa-miR-1260b | cancer | MNDR Database |
| hsa-miR-1260b | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| hsa-miR-1260b | cholangiocarcinoma | MNDR Database |
| hsa-miR-1260b | chordoma | MNDR Database |
| hsa-miR-1260b | esophageal cancer | MNDR Database |
| hsa-miR-1260b | Kawasaki disease | MNDR Database |
| hsa-miR-1260b | Liver Neoplasms | MNDR Database |
| hsa-miR-1260b | malignant glioma | MNDR Database |
| hsa-miR-1260b | medulloblastoma | MNDR Database |
| hsa-miR-1260b | neuromyelitis optica | MNDR Database |
| hsa-miR-1260b | Ovarian Neoplasms | MNDR Database |
| hsa-miR-1260b | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-1260b | pancreatic cancer | MNDR Database |
| hsa-miR-1260b | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-1260b | renal cell carcinoma | MNDR Database |
| hsa-miR-1260b | stomach cancer | MNDR Database |
| hsa-miR-1260b | spinocerebellar ataxia, autosomal recessive 16 | eDGAR Database |