Interaction ID
ncRI-40658738
Interaction Molecules
hsa-miR-766-3p -- SESN1
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T;HEK293S;Cingulategyrus;normal
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000080546
Description
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).
| Pubmed ID | 23824327 | Journal | Genes & development |
|---|---|---|---|
| Title | Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. | ||
| Author | Karginov FV, Hannon GJ | ||
| Pubmed ID | 24389009 | Journal | Neuron |
|---|---|---|---|
| Title | Transcriptome-wide discovery of microRNA binding sites in human brain. | ||
| Author | Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL | ||
| Pubmed ID | 28735896 | Journal | Molecular cell |
|---|---|---|---|
| Title | Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. | ||
| Author | Luna JM, Barajas JM, Teng KY, Sun HL, Moore MJ, Rice CM, Darnell RB, Ghoshal K | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-766-3p | acute T cell leukemia | MNDR Database |
| hsa-miR-766-3p | Adrenocortical Carcinoma | MNDR Database |
| hsa-miR-766-3p | Alzheimer's disease | MNDR Database |
| hsa-miR-766-3p | amyotrophic lateral sclerosis | MNDR Database |
| hsa-miR-766-3p | Barrett's adenocarcinoma | MNDR Database |
| hsa-miR-766-3p | bladder urothelial carcinoma | MNDR Database |
| hsa-miR-766-3p | breast cancer | MNDR Database |
| hsa-miR-766-3p | Breast Neoplasms | MNDR Database |
| hsa-miR-766-3p | cancer | MNDR Database |
| hsa-miR-766-3p | Carcinoma, Ductal, Breast | MNDR Database |
| hsa-miR-766-3p | Carcinoma, Renal Cell | MNDR Database |
| hsa-miR-766-3p | cholangiocarcinoma | MNDR Database |
| hsa-miR-766-3p | colon adenocarcinoma | MNDR Database |
| hsa-miR-766-3p | colon cancer | MNDR Database |
| hsa-miR-766-3p | colorectal cancer | MNDR Database |
| hsa-miR-766-3p | esophageal cancer | MNDR Database |
| hsa-miR-766-3p | gastric adenocarcinoma | MNDR Database |
| hsa-miR-766-3p | head and neck cancer | MNDR Database |
| hsa-miR-766-3p | head and neck squamous cell carcinoma | MNDR Database |
| hsa-miR-766-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-766-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-766-3p | Intracranial Hemorrhage, Hypertensive | MNDR Database |
| hsa-miR-766-3p | large cell carcinoma | MNDR Database |
| hsa-miR-766-3p | leukemia | MNDR Database |
| hsa-miR-766-3p | lung cancer | MNDR Database |
| hsa-miR-766-3p | lung squamous cell carcinoma | MNDR Database |
| hsa-miR-766-3p | malignant glioma | MNDR Database |
| hsa-miR-766-3p | malignant pleural mesothelioma | MNDR Database |
| hsa-miR-766-3p | medulloblastoma | MNDR Database |
| hsa-miR-766-3p | melanoma | MNDR Database |
| hsa-miR-766-3p | Myasthenia Gravis, Autoimmune, Experimental | MNDR Database |
| hsa-miR-766-3p | nasopharynx carcinoma | MNDR Database |
| hsa-miR-766-3p | nephroblastoma | MNDR Database |
| hsa-miR-766-3p | neuromyelitis optica | MNDR Database |
| hsa-miR-766-3p | osteosarcoma | MNDR Database |
| hsa-miR-766-3p | ovarian carcinoma | MNDR Database |
| hsa-miR-766-3p | Ovarian Neoplasms | MNDR Database |
| hsa-miR-766-3p | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-766-3p | pancreatic cancer | MNDR Database |
| hsa-miR-766-3p | papillary renal cell carcinoma | MNDR Database |
| hsa-miR-766-3p | polycystic ovary syndrome | MNDR Database |
| hsa-miR-766-3p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-766-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-766-3p | prostate adenocarcinoma | MNDR Database |
| hsa-miR-766-3p | rectum adenocarcinoma | MNDR Database |
| hsa-miR-766-3p | renal cell carcinoma | MNDR Database |
| hsa-miR-766-3p | renal clear cell carcinoma | MNDR Database |
| hsa-miR-766-3p | retinoblastoma | MNDR Database |
| hsa-miR-766-3p | skin melanoma | MNDR Database |
| hsa-miR-766-3p | stomach cancer | MNDR Database |
| hsa-miR-766-3p | uterine corpus endometrial carcinoma | MNDR Database |
| hsa-miR-766-3p | vascular disease | MNDR Database |