Interaction ID
ncRI-40658627
Interaction Molecules
hsa-miR-624-3p -- SMARCD1
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000066117
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342).
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-624-3p | adenoma | MNDR Database |
| hsa-miR-624-3p | B-cell lymphoma | MNDR Database |
| hsa-miR-624-3p | brain disease | MNDR Database |
| hsa-miR-624-3p | breast cancer | MNDR Database |
| hsa-miR-624-3p | Breast Neoplasms | MNDR Database |
| hsa-miR-624-3p | cancer | MNDR Database |
| hsa-miR-624-3p | carcinoma | MNDR Database |
| hsa-miR-624-3p | cholangiocarcinoma | MNDR Database |
| hsa-miR-624-3p | colon cancer | MNDR Database |
| hsa-miR-624-3p | colorectal cancer | MNDR Database |
| hsa-miR-624-3p | coronary artery disease | MNDR Database |
| hsa-miR-624-3p | embryonal cancer | MNDR Database |
| hsa-miR-624-3p | eye disease | MNDR Database |
| hsa-miR-624-3p | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-624-3p | gastric adenocarcinoma | MNDR Database |
| hsa-miR-624-3p | Glioblastoma | MNDR Database |
| hsa-miR-624-3p | head and neck cancer | MNDR Database |
| hsa-miR-624-3p | head and neck squamous cell carcinoma | MNDR Database |
| hsa-miR-624-3p | heart disease | MNDR Database |
| hsa-miR-624-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-624-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-624-3p | Huntington's disease | MNDR Database |
| hsa-miR-624-3p | kidney disease | MNDR Database |
| hsa-miR-624-3p | leukemia | MNDR Database |
| hsa-miR-624-3p | lung adenocarcinoma | MNDR Database |
| hsa-miR-624-3p | lung cancer | MNDR Database |
| hsa-miR-624-3p | lung squamous cell carcinoma | MNDR Database |
| hsa-miR-624-3p | lymphoma | MNDR Database |
| hsa-miR-624-3p | malignant glioma | MNDR Database |
| hsa-miR-624-3p | malignant pleural mesothelioma | MNDR Database |
| hsa-miR-624-3p | medulloblastoma | MNDR Database |
| hsa-miR-624-3p | melanoma | MNDR Database |
| hsa-miR-624-3p | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| hsa-miR-624-3p | nasopharynx carcinoma | MNDR Database |
| hsa-miR-624-3p | nephroblastoma | MNDR Database |
| hsa-miR-624-3p | neurodegenerative disease | MNDR Database |
| hsa-miR-624-3p | oral squamous cell carcinoma | MNDR Database |
| hsa-miR-624-3p | osteosarcoma | MNDR Database |
| hsa-miR-624-3p | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-624-3p | pancreatic cancer | MNDR Database |
| hsa-miR-624-3p | papillary renal cell carcinoma | MNDR Database |
| hsa-miR-624-3p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-624-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-624-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-624-3p | renal cell carcinoma | MNDR Database |
| hsa-miR-624-3p | renal clear cell carcinoma | MNDR Database |
| hsa-miR-624-3p | stomach cancer | MNDR Database |
| hsa-miR-624-3p | Subarachnoid Hemorrhage, Traumatic | MNDR Database |
| hsa-miR-624-3p | testicular germ cell cancer | MNDR Database |
| hsa-miR-624-3p | thyroid carcinoma | MNDR Database |
| hsa-miR-624-3p | vascular disease | MNDR Database |