Interaction Profile
Interaction ID
ncRI-40657968
Interaction Molecules
hsa-miR-421 -- TMEM107
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293T;T-REx-293T;HEK293S;Cingulategyrus;normal;Left ventricle;tumor;motor cortex
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Molecule Profile
Alias
-
Class
mRNA
Ensembl id
ENSG00000179029
Description
Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474).
Reference Information
| Pubmed ID | 23824327 | Journal | Genes & development |
|---|---|---|---|
| Title | Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. | ||
| Author | Karginov FV, Hannon GJ | ||
| Pubmed ID | 24389009 | Journal | Neuron |
|---|---|---|---|
| Title | Transcriptome-wide discovery of microRNA binding sites in human brain. | ||
| Author | Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL | ||
| Pubmed ID | 27418678 | Journal | Nucleic acids research |
|---|---|---|---|
| Title | Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP. | ||
| Author | Spengler RM, Zhang X, Cheng C, McLendon JM, Skeie JM, Johnson FL, Davidson BL, Boudreau RL | ||
| Pubmed ID | 28735896 | Journal | Molecular cell |
|---|---|---|---|
| Title | Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. | ||
| Author | Luna JM, Barajas JM, Teng KY, Sun HL, Moore MJ, Rice CM, Darnell RB, Ghoshal K | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-421 | Adenoviridae Infections | MNDR Database |
| hsa-miR-421 | Alzheimer's disease | MNDR Database |
| hsa-miR-421 | anencephaly | MNDR Database |
| hsa-miR-421 | ataxia telangiectasia | MNDR Database |
| hsa-miR-421 | biliary tract neoplasm | MNDR Database |
| hsa-miR-421 | bladder urothelial carcinoma | MNDR Database |
| hsa-miR-421 | brain disease | MNDR Database |
| hsa-miR-421 | breast cancer | MNDR Database |
| hsa-miR-421 | Breast Neoplasms | MNDR Database |
| hsa-miR-421 | cancer | MNDR Database |
| hsa-miR-421 | carcinoma | MNDR Database |
| hsa-miR-421 | Carcinoma, Ductal, Breast | MNDR Database |
| hsa-miR-421 | cholangiocarcinoma | MNDR Database |
| hsa-miR-421 | colon cancer | MNDR Database |
| hsa-miR-421 | colorectal cancer | MNDR Database |
| hsa-miR-421 | diabetes mellitus | MNDR Database |
| hsa-miR-421 | esophageal carcinoma | MNDR Database |
| hsa-miR-421 | eye disease | MNDR Database |
| hsa-miR-421 | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-421 | gastric adenocarcinoma | MNDR Database |
| hsa-miR-421 | Glioblastoma | MNDR Database |
| hsa-miR-421 | head and neck cancer | MNDR Database |
| hsa-miR-421 | head and neck squamous cell carcinoma | MNDR Database |
| hsa-miR-421 | heart disease | MNDR Database |
| hsa-miR-421 | hepatocellular carcinoma | MNDR Database |
| hsa-miR-421 | Hodgkin's lymphoma | MNDR Database |
| hsa-miR-421 | Huntington's disease | MNDR Database |
| hsa-miR-421 | Intracranial Hemorrhage, Hypertensive | MNDR Database |
| hsa-miR-421 | large cell carcinoma | MNDR Database |
| hsa-miR-421 | large cell neuroendocrine cancer | MNDR Database |
| hsa-miR-421 | leukemia | MNDR Database |
| hsa-miR-421 | lung adenocarcinoma | MNDR Database |
| hsa-miR-421 | lung cancer | MNDR Database |
| hsa-miR-421 | lung disease | MNDR Database |
| hsa-miR-421 | lung small cell carcinoma | MNDR Database |
| hsa-miR-421 | lung squamous cell carcinoma | MNDR Database |
| hsa-miR-421 | lymphoma | MNDR Database |
| hsa-miR-421 | malignant glioma | MNDR Database |
| hsa-miR-421 | malignant pleural mesothelioma | MNDR Database |
| hsa-miR-421 | melanoma | MNDR Database |
| hsa-miR-421 | multiple myeloma | MNDR Database |
| hsa-miR-421 | Myasthenia Gravis, Autoimmune, Experimental | MNDR Database |
| hsa-miR-421 | nasopharynx carcinoma | MNDR Database |
| hsa-miR-421 | nephroblastoma | MNDR Database |
| hsa-miR-421 | neuroblastoma | MNDR Database |
| hsa-miR-421 | neurodegenerative disease | MNDR Database |
| hsa-miR-421 | oral squamous cell carcinoma | MNDR Database |
| hsa-miR-421 | osteosarcoma | MNDR Database |
| hsa-miR-421 | ovarian carcinoma | MNDR Database |
| hsa-miR-421 | Ovarian Neoplasms | MNDR Database |
| hsa-miR-421 | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-421 | pancreatic cancer | MNDR Database |
| hsa-miR-421 | papillary renal cell carcinoma | MNDR Database |
| hsa-miR-421 | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-421 | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-421 | Prostatic Neoplasms | MNDR Database |
| hsa-miR-421 | pulmonary tuberculosis | MNDR Database |
| hsa-miR-421 | renal clear cell carcinoma | MNDR Database |
| hsa-miR-421 | skin disease | MNDR Database |
| hsa-miR-421 | squamous cell carcinoma | MNDR Database |
| hsa-miR-421 | stomach cancer | MNDR Database |
| hsa-miR-421 | stomach carcinoma | MNDR Database |
| hsa-miR-421 | Subarachnoid Hemorrhage, Traumatic | MNDR Database |
| hsa-miR-421 | thyroid cancer | MNDR Database |
| hsa-miR-421 | thyroid carcinoma | MNDR Database |
| hsa-miR-421 | uterine corpus endometrial carcinoma | MNDR Database |
| hsa-miR-421 | vascular disease | MNDR Database |