Interaction ID
ncRI-40657093
Interaction Molecules
hsa-miR-3153 -- VRK2
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T;motor cortex
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000028116
Description
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
| Pubmed ID | 24389009 | Journal | Neuron |
|---|---|---|---|
| Title | Transcriptome-wide discovery of microRNA binding sites in human brain. | ||
| Author | Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-3153 | biliary tract cancer | MNDR Database |
| hsa-miR-3153 | cancer | MNDR Database |
| hsa-miR-3153 | cholangiocarcinoma | MNDR Database |
| hsa-miR-3153 | colon cancer | MNDR Database |
| hsa-miR-3153 | colorectal cancer | MNDR Database |
| hsa-miR-3153 | esophageal cancer | MNDR Database |
| hsa-miR-3153 | Liver Neoplasms | MNDR Database |
| hsa-miR-3153 | nephroblastoma | MNDR Database |
| hsa-miR-3153 | pancreatic ductal adenocarcinoma | MNDR Database |
| hsa-miR-3153 | progressive supranuclear palsy | MNDR Database |
| hsa-miR-3153 | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-3153 | stomach cancer | MNDR Database |