Interaction: ncRI-40656659

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Interaction Profile

Interaction ID

ncRI-40656659

Interaction Molecules

hsa-miR-551b-3p -- SPPL2A

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-551b-3p

⇔

SPPL2A

Alias

-

Class

miRNA

miRBase id

MI0003575

Description

Homo sapiens miR-551b stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000138600

Description

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).

Reference Information
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-551b-3p acute myeloid leukemia MNDR Database
hsa-miR-551b-3p acute T cell leukemia MNDR Database
hsa-miR-551b-3p Alzheimer's disease MNDR Database
hsa-miR-551b-3p amyotrophic lateral sclerosis MNDR Database
hsa-miR-551b-3p autosomal recessive disease MNDR Database
hsa-miR-551b-3p B-cell lymphoma MNDR Database
hsa-miR-551b-3p biliary tract cancer MNDR Database
hsa-miR-551b-3p bladder urothelial carcinoma MNDR Database
hsa-miR-551b-3p bone disease MNDR Database
hsa-miR-551b-3p brain disease MNDR Database
hsa-miR-551b-3p breast cancer MNDR Database
hsa-miR-551b-3p Breast Neoplasms MNDR Database
hsa-miR-551b-3p Burkitt lymphoma MNDR Database
hsa-miR-551b-3p cancer MNDR Database
hsa-miR-551b-3p carcinoma MNDR Database
hsa-miR-551b-3p Carcinoma, Ductal, Breast MNDR Database
hsa-miR-551b-3p cholangiocarcinoma MNDR Database
hsa-miR-551b-3p colon cancer MNDR Database
hsa-miR-551b-3p colorectal cancer MNDR Database
hsa-miR-551b-3p diabetes mellitus MNDR Database
hsa-miR-551b-3p Ependymoma MNDR Database
hsa-miR-551b-3p esophageal cancer MNDR Database
hsa-miR-551b-3p familiar ovarian carcinoma MNDR Database
hsa-miR-551b-3p gastric adenocarcinoma MNDR Database
hsa-miR-551b-3p Glioblastoma MNDR Database
hsa-miR-551b-3p hepatocellular carcinoma MNDR Database
hsa-miR-551b-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-551b-3p Hodgkin's lymphoma MNDR Database
hsa-miR-551b-3p large cell neuroendocrine cancer MNDR Database
hsa-miR-551b-3p leukemia MNDR Database
hsa-miR-551b-3p Liver Neoplasms MNDR Database
hsa-miR-551b-3p lung adenocarcinoma MNDR Database
hsa-miR-551b-3p lung cancer MNDR Database
hsa-miR-551b-3p lung disease MNDR Database
hsa-miR-551b-3p lung small cell carcinoma MNDR Database
hsa-miR-551b-3p lung squamous cell carcinoma MNDR Database
hsa-miR-551b-3p lymphoma MNDR Database
hsa-miR-551b-3p malignant glioma MNDR Database
hsa-miR-551b-3p malignant pleural mesothelioma MNDR Database
hsa-miR-551b-3p medulloblastoma MNDR Database
hsa-miR-551b-3p melanoma MNDR Database
hsa-miR-551b-3p multiple myeloma MNDR Database
hsa-miR-551b-3p nasopharynx carcinoma MNDR Database
hsa-miR-551b-3p neurodegenerative disease MNDR Database
hsa-miR-551b-3p osteosarcoma MNDR Database
hsa-miR-551b-3p Ovarian Neoplasms MNDR Database
hsa-miR-551b-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-551b-3p pancreatic cancer MNDR Database
hsa-miR-551b-3p papillary renal cell carcinoma MNDR Database
hsa-miR-551b-3p pituitary adenoma MNDR Database
hsa-miR-551b-3p Precursor Cell Lymphoblastic Leukemia-Lymphoma MNDR Database
hsa-miR-551b-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-551b-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-551b-3p renal clear cell carcinoma MNDR Database
hsa-miR-551b-3p stomach cancer MNDR Database
hsa-miR-551b-3p stomach carcinoma MNDR Database
hsa-miR-551b-3p Stroke, Lacunar MNDR Database
hsa-miR-551b-3p synovial sarcoma MNDR Database
hsa-miR-551b-3p thyroid cancer MNDR Database
hsa-miR-551b-3p thyroid carcinoma MNDR Database
hsa-miR-551b-3p uterine corpus endometrial carcinoma MNDR Database
hsa-miR-551b-3p vascular disease MNDR Database