Interaction ID
ncRI-40651764
Interaction Molecules
hsa-miR-568 -- SPPL2A
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000138600
Description
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-568 | autosomal recessive disease | MNDR Database |
| hsa-miR-568 | bone disease | MNDR Database |
| hsa-miR-568 | brain disease | MNDR Database |
| hsa-miR-568 | breast cancer | MNDR Database |
| hsa-miR-568 | Breast Neoplasms | MNDR Database |
| hsa-miR-568 | cancer | MNDR Database |
| hsa-miR-568 | carcinoma | MNDR Database |
| hsa-miR-568 | chronic myeloid leukemia | MNDR Database |
| hsa-miR-568 | colon cancer | MNDR Database |
| hsa-miR-568 | colorectal cancer | MNDR Database |
| hsa-miR-568 | diabetes mellitus | MNDR Database |
| hsa-miR-568 | eye disease | MNDR Database |
| hsa-miR-568 | head and neck cancer | MNDR Database |
| hsa-miR-568 | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-568 | hypersensitivity reaction type II disease | MNDR Database |
| hsa-miR-568 | intellectual disability | MNDR Database |
| hsa-miR-568 | leukemia | MNDR Database |
| hsa-miR-568 | lung cancer | MNDR Database |
| hsa-miR-568 | lung disease | MNDR Database |
| hsa-miR-568 | lymphoma | MNDR Database |
| hsa-miR-568 | malignant glioma | MNDR Database |
| hsa-miR-568 | malignant pleural mesothelioma | MNDR Database |
| hsa-miR-568 | melanoma | MNDR Database |
| hsa-miR-568 | nephroblastoma | MNDR Database |
| hsa-miR-568 | neurodegenerative disease | MNDR Database |
| hsa-miR-568 | Ovarian Neoplasms | MNDR Database |
| hsa-miR-568 | pancreatic cancer | MNDR Database |
| hsa-miR-568 | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-568 | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-568 | Prostatic Neoplasms | MNDR Database |
| hsa-miR-568 | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-568 | stomach cancer | MNDR Database |
| hsa-miR-568 | vascular disease | MNDR Database |