Interaction ID
ncRI-40649674
Interaction Molecules
hsa-miR-3185 -- SMARCD1
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T;motor cortex
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000066117
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342).
| Pubmed ID | 24389009 | Journal | Neuron |
|---|---|---|---|
| Title | Transcriptome-wide discovery of microRNA binding sites in human brain. | ||
| Author | Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-3185 | acromegaly | MNDR Database |
| hsa-miR-3185 | amyotrophic lateral sclerosis | MNDR Database |
| hsa-miR-3185 | biliary tract cancer | MNDR Database |
| hsa-miR-3185 | cancer | MNDR Database |
| hsa-miR-3185 | cholangiocarcinoma | MNDR Database |
| hsa-miR-3185 | chordoma | MNDR Database |
| hsa-miR-3185 | colon cancer | MNDR Database |
| hsa-miR-3185 | esophageal cancer | MNDR Database |
| hsa-miR-3185 | Hodgkin's lymphoma | MNDR Database |
| hsa-miR-3185 | Liver Neoplasms | MNDR Database |
| hsa-miR-3185 | nephroblastoma | MNDR Database |
| hsa-miR-3185 | Non-alcoholic Fatty Liver Disease | MNDR Database |
| hsa-miR-3185 | pancreatic cancer | MNDR Database |
| hsa-miR-3185 | progressive supranuclear palsy | MNDR Database |
| hsa-miR-3185 | stomach cancer | MNDR Database |