Interaction: ncRI-40649068

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Interaction Profile

Interaction ID

ncRI-40649068

Interaction Molecules

hsa-miR-200c-3p -- GLI3

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

TargetScan with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-200c-3p

⇔

GLI3

Alias

-

Class

miRNA

miRBase id

MI0000650

Description

Homo sapiens miR-200c stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000106571

Description

Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.

Reference Information
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-200c-3p Abortion, Habitual MNDR Database
hsa-miR-200c-3p acromegaly MNDR Database
hsa-miR-200c-3p ACTH-secreting pituitary adenoma MNDR Database
hsa-miR-200c-3p acute myeloid leukemia MNDR Database
hsa-miR-200c-3p acute promyelocytic leukemia MNDR Database
hsa-miR-200c-3p acute T cell leukemia MNDR Database
hsa-miR-200c-3p Acute Coronary Syndrome MNDR Database
hsa-miR-200c-3p adenocarcinoma MNDR Database
hsa-miR-200c-3p Adenoviridae Infections MNDR Database
hsa-miR-200c-3p adrenal cortex cancer MNDR Database
hsa-miR-200c-3p adrenal cortical adenoma MNDR Database
hsa-miR-200c-3p adrenocortical carcinoma MNDR Database
hsa-miR-200c-3p adult T-cell leukemia MNDR Database
hsa-miR-200c-3p Aging MNDR Database
hsa-miR-200c-3p allergic rhinitis MNDR Database
hsa-miR-200c-3p alopecia MNDR Database
hsa-miR-200c-3p Alzheimer's disease MNDR Database
hsa-miR-200c-3p amyloidosis MNDR Database
hsa-miR-200c-3p angiosarcoma MNDR Database
hsa-miR-200c-3p anxiety disorder MNDR Database
hsa-miR-200c-3p aortic valve stenosis MNDR Database
hsa-miR-200c-3p arthritis MNDR Database
hsa-miR-200c-3p asthma MNDR Database
hsa-miR-200c-3p astrocytoma MNDR Database
hsa-miR-200c-3p atherosclerosis MNDR Database
hsa-miR-200c-3p atrial fibrillation MNDR Database
hsa-miR-200c-3p autistic disorder MNDR Database
hsa-miR-200c-3p autosomal dominant disease MNDR Database
hsa-miR-200c-3p autosomal recessive disease MNDR Database
hsa-miR-200c-3p azoospermia MNDR Database
hsa-miR-200c-3p Barrett's esophagus MNDR Database
hsa-miR-200c-3p basal cell carcinoma MNDR Database
hsa-miR-200c-3p B-cell lymphoma MNDR Database
hsa-miR-200c-3p biliary tract cancer MNDR Database
hsa-miR-200c-3p biliary tract neoplasm MNDR Database
hsa-miR-200c-3p bladder urothelial carcinoma MNDR Database
hsa-miR-200c-3p bone disease MNDR Database
hsa-miR-200c-3p brain cancer MNDR Database
hsa-miR-200c-3p brain disease MNDR Database
hsa-miR-200c-3p breast cancer MNDR Database
hsa-miR-200c-3p Breast Neoplasms MNDR Database
hsa-miR-200c-3p Burkitt lymphoma MNDR Database
hsa-miR-200c-3p cancer MNDR Database
hsa-miR-200c-3p carcinoma MNDR Database
hsa-miR-200c-3p Carcinoma, Ductal, Breast MNDR Database
hsa-miR-200c-3p Carcinoma, Non-Small-Cell Lung MNDR Database
hsa-miR-200c-3p Carcinoma, Renal Cell MNDR Database
hsa-miR-200c-3p Cardiomegaly MNDR Database
hsa-miR-200c-3p cardiomyopathy MNDR Database
hsa-miR-200c-3p centronuclear myopathy MNDR Database
hsa-miR-200c-3p cerebral infarction MNDR Database
hsa-miR-200c-3p Cerebral Hemorrhage MNDR Database
hsa-miR-200c-3p cervical adenocarcinoma MNDR Database
hsa-miR-200c-3p cervical squamous cell carcinoma MNDR Database
hsa-miR-200c-3p cholangiocarcinoma MNDR Database
hsa-miR-200c-3p cholestatic liver MNDR Database
hsa-miR-200c-3p cholesteatoma MNDR Database
hsa-miR-200c-3p choriocarcinoma MNDR Database
hsa-miR-200c-3p chronic kidney disease MNDR Database
hsa-miR-200c-3p chronic lymphocytic leukemia MNDR Database
hsa-miR-200c-3p chronic myeloid leukemia MNDR Database
hsa-miR-200c-3p chronic obstructive pulmonary disease MNDR Database
hsa-miR-200c-3p Cocaine-Related Disorders MNDR Database
hsa-miR-200c-3p colon adenocarcinoma MNDR Database
hsa-miR-200c-3p colon cancer MNDR Database
hsa-miR-200c-3p colorectal cancer MNDR Database
hsa-miR-200c-3p corneal dystrophy MNDR Database
hsa-miR-200c-3p coronary artery disease MNDR Database
hsa-miR-200c-3p Crohn's disease MNDR Database
hsa-miR-200c-3p cryptosporidiosis MNDR Database
hsa-miR-200c-3p demyelinating disease MNDR Database
hsa-miR-200c-3p diabetes mellitus MNDR Database
hsa-miR-200c-3p Diabetic Nephropathies MNDR Database
hsa-miR-200c-3p diffuse large B-cell lymphoma MNDR Database
hsa-miR-200c-3p Digestive System Neoplasms MNDR Database
hsa-miR-200c-3p dilated cardiomyopathy MNDR Database
hsa-miR-200c-3p distal muscular dystrophy MNDR Database
hsa-miR-200c-3p Down syndrome MNDR Database
hsa-miR-200c-3p Duchenne muscular dystrophy MNDR Database
hsa-miR-200c-3p eclampsia MNDR Database
hsa-miR-200c-3p Ehrlich tumor carcinoma MNDR Database
hsa-miR-200c-3p endometrial adenocarcinoma MNDR Database
hsa-miR-200c-3p endometrial cancer MNDR Database
hsa-miR-200c-3p endometriosis MNDR Database
hsa-miR-200c-3p endomyocardial fibrosis MNDR Database
hsa-miR-200c-3p eosinophilic esophagitis MNDR Database
hsa-miR-200c-3p Ependymoma MNDR Database
hsa-miR-200c-3p esophageal cancer MNDR Database
hsa-miR-200c-3p Esophagus MNDR Database
hsa-miR-200c-3p Ewing sarcoma MNDR Database
hsa-miR-200c-3p eye disease MNDR Database
hsa-miR-200c-3p facioscapulohumeral muscular dystrophy MNDR Database
hsa-miR-200c-3p familiar ovarian carcinoma MNDR Database
hsa-miR-200c-3p fatty liver disease MNDR Database
hsa-miR-200c-3p Fatty Liver MNDR Database
hsa-miR-200c-3p Fibrosis MNDR Database
hsa-miR-200c-3p gastric adenocarcinoma MNDR Database
hsa-miR-200c-3p gastrointestinal system cancer MNDR Database
hsa-miR-200c-3p Glioblastoma MNDR Database
hsa-miR-200c-3p gout MNDR Database
hsa-miR-200c-3p Growth Hormone-Secreting Pituitary Adenoma MNDR Database
hsa-miR-200c-3p hand, foot and mouth disease MNDR Database
hsa-miR-200c-3p head and neck cancer MNDR Database
hsa-miR-200c-3p head and neck squamous cell carcinoma MNDR Database
hsa-miR-200c-3p heart disease MNDR Database
hsa-miR-200c-3p Heart Defects, Congenital MNDR Database
hsa-miR-200c-3p Heart Failure MNDR Database
hsa-miR-200c-3p Helplessness, Learned MNDR Database
hsa-miR-200c-3p hematologic cancer MNDR Database
hsa-miR-200c-3p hepatitis B MNDR Database
hsa-miR-200c-3p hepatitis C MNDR Database
hsa-miR-200c-3p hepatitis MNDR Database
hsa-miR-200c-3p hepatoblastoma MNDR Database
hsa-miR-200c-3p hepatocellular carcinoma MNDR Database
hsa-miR-200c-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-200c-3p HIV Infections MNDR Database
hsa-miR-200c-3p HIV MNDR Database
hsa-miR-200c-3p HIV-1 MNDR Database
hsa-miR-200c-3p Hodgkin's lymphoma MNDR Database
hsa-miR-200c-3p Huntington's disease MNDR Database
hsa-miR-200c-3p hypersensitivity reaction type II disease MNDR Database
hsa-miR-200c-3p hypertension MNDR Database
hsa-miR-200c-3p hypertrophic cardiomyopathy MNDR Database
hsa-miR-200c-3p Hypertrophy MNDR Database
hsa-miR-200c-3p Hypertrophy, Left Ventricular MNDR Database
hsa-miR-200c-3p idiopathic pulmonary fibrosis MNDR Database
hsa-miR-200c-3p IgA glomerulonephritis MNDR Database
hsa-miR-200c-3p Inflammation MNDR Database
hsa-miR-200c-3p inflammatory bowel disease MNDR Database
hsa-miR-200c-3p Influenza, Human MNDR Database
hsa-miR-200c-3p intellectual disability MNDR Database
hsa-miR-200c-3p interstitial cystitis MNDR Database
hsa-miR-200c-3p interstitial lung disease MNDR Database
hsa-miR-200c-3p intracranial abscess MNDR Database
hsa-miR-200c-3p intrahepatic cholangiocarcinoma MNDR Database
hsa-miR-200c-3p ischemia MNDR Database
hsa-miR-200c-3p Kaposi's sarcoma MNDR Database
hsa-miR-200c-3p kidney cancer MNDR Database
hsa-miR-200c-3p kidney disease MNDR Database
hsa-miR-200c-3p Kidney Neoplasms MNDR Database
hsa-miR-200c-3p large cell carcinoma MNDR Database
hsa-miR-200c-3p large cell neuroendocrine cancer MNDR Database
hsa-miR-200c-3p Laryngeal Neoplasms MNDR Database
hsa-miR-200c-3p leiomyoma MNDR Database
hsa-miR-200c-3p leukemia MNDR Database
hsa-miR-200c-3p Leukemia, B-Cell MNDR Database
hsa-miR-200c-3p Leukemia, Biphenotypic, Acute MNDR Database
hsa-miR-200c-3p Leukemia, Myeloid, Chronic-Phase MNDR Database
hsa-miR-200c-3p Lichen Planus, Oral MNDR Database
hsa-miR-200c-3p liposarcoma MNDR Database
hsa-miR-200c-3p liver cirrhosis MNDR Database
hsa-miR-200c-3p liver disease MNDR Database
hsa-miR-200c-3p Liver Failure MNDR Database
hsa-miR-200c-3p Liver Neoplasms MNDR Database
hsa-miR-200c-3p lung adenocarcinoma MNDR Database
hsa-miR-200c-3p lung cancer MNDR Database
hsa-miR-200c-3p lung disease MNDR Database
hsa-miR-200c-3p lung small cell carcinoma MNDR Database
hsa-miR-200c-3p lung squamous cell carcinoma MNDR Database
hsa-miR-200c-3p lupus nephritis MNDR Database
hsa-miR-200c-3p Lupus Vulgaris MNDR Database
hsa-miR-200c-3p lymphoma MNDR Database
hsa-miR-200c-3p Lymphoma, Large-Cell, Anaplastic MNDR Database
hsa-miR-200c-3p Lymphoma, Primary Effusion MNDR Database
hsa-miR-200c-3p Lymphoma, T-Cell MNDR Database
hsa-miR-200c-3p lymphoplasmacytic lymphoma MNDR Database
hsa-miR-200c-3p male infertility MNDR Database
hsa-miR-200c-3p malignant glioma MNDR Database
hsa-miR-200c-3p mantle cell lymphoma MNDR Database
hsa-miR-200c-3p Marek Disease MNDR Database
hsa-miR-200c-3p medulloblastoma MNDR Database
hsa-miR-200c-3p melanoma MNDR Database
hsa-miR-200c-3p meningioma MNDR Database
hsa-miR-200c-3p mesenchymal cell neoplasm MNDR Database
hsa-miR-200c-3p Mesothelioma MNDR Database
hsa-miR-200c-3p Mouth Neoplasms MNDR Database
hsa-miR-200c-3p Moyamoya disease MNDR Database
hsa-miR-200c-3p mucinous cystadenocarcinoma MNDR Database
hsa-miR-200c-3p multiple myeloma MNDR Database
hsa-miR-200c-3p multiple sclerosis MNDR Database
hsa-miR-200c-3p Multiple Sclerosis, Chronic Progressive MNDR Database
hsa-miR-200c-3p muscular dystrophy MNDR Database
hsa-miR-200c-3p Muscular Disorders, Atrophic MNDR Database
hsa-miR-200c-3p Musculoskeletal Abnormalities MNDR Database
hsa-miR-200c-3p Myasthenia Gravis, Autoimmune, Experimental MNDR Database
hsa-miR-200c-3p mycosis fungoides MNDR Database
hsa-miR-200c-3p myelodysplastic/myeloproliferative neoplasm MNDR Database
hsa-miR-200c-3p myeloid leukemia MNDR Database
hsa-miR-200c-3p Myeloproliferative Disorders MNDR Database
hsa-miR-200c-3p myocardial infarction MNDR Database
hsa-miR-200c-3p Myocardial Ischemia MNDR Database
hsa-miR-200c-3p Myocardial Reperfusion Injury MNDR Database
hsa-miR-200c-3p Myocardium MNDR Database
hsa-miR-200c-3p Myocytes, Cardiac MNDR Database
hsa-miR-200c-3p myopathy MNDR Database
hsa-miR-200c-3p Myotonic Dystrophy MNDR Database
hsa-miR-200c-3p nasopharynx carcinoma MNDR Database
hsa-miR-200c-3p Neoplasms MNDR Database
hsa-miR-200c-3p nephroblastoma MNDR Database
hsa-miR-200c-3p nephrosclerosis MNDR Database
hsa-miR-200c-3p neuroblastoma MNDR Database
hsa-miR-200c-3p neurodegenerative disease MNDR Database
hsa-miR-200c-3p Non-alcoholic Fatty Liver Disease MNDR Database
hsa-miR-200c-3p non-Hodgkin lymphoma MNDR Database
hsa-miR-200c-3p obesity MNDR Database
hsa-miR-200c-3p ophthalmoplegia MNDR Database
hsa-miR-200c-3p oral squamous cell carcinoma MNDR Database
hsa-miR-200c-3p orbital cellulitis MNDR Database
hsa-miR-200c-3p oropharynx cancer MNDR Database
hsa-miR-200c-3p osteoarthritis MNDR Database
hsa-miR-200c-3p osteosarcoma MNDR Database
hsa-miR-200c-3p ovarian carcinoma MNDR Database
hsa-miR-200c-3p ovarian clear cell carcinoma MNDR Database
hsa-miR-200c-3p ovarian endometrial cancer MNDR Database
hsa-miR-200c-3p Ovarian epithelial cancer MNDR Database
hsa-miR-200c-3p Ovarian Neoplasms MNDR Database
hsa-miR-200c-3p Pain MNDR Database
hsa-miR-200c-3p pancreatic cancer MNDR Database
hsa-miR-200c-3p pancreatic ductal adenocarcinoma MNDR Database
hsa-miR-200c-3p panic disorder MNDR Database
hsa-miR-200c-3p papillary renal cell carcinoma MNDR Database
hsa-miR-200c-3p Parkinson's disease MNDR Database
hsa-miR-200c-3p periodontal disease MNDR Database
hsa-miR-200c-3p periodontitis MNDR Database
hsa-miR-200c-3p Pheochromocytoma MNDR Database
hsa-miR-200c-3p pituitary adenoma MNDR Database
hsa-miR-200c-3p Polycystic Kidney Diseases MNDR Database
hsa-miR-200c-3p polycythemia vera MNDR Database
hsa-miR-200c-3p Precursor B-Cell Lymphoblastic Leukemia-Lymphoma MNDR Database
hsa-miR-200c-3p Precursor Cell Lymphoblastic Leukemia-Lymphoma MNDR Database
hsa-miR-200c-3p pre-eclampsia MNDR Database
hsa-miR-200c-3p primary pulmonary hypertension MNDR Database
hsa-miR-200c-3p prion disease MNDR Database
hsa-miR-200c-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-200c-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-200c-3p prolactinoma MNDR Database
hsa-miR-200c-3p prostate adenocarcinoma MNDR Database
hsa-miR-200c-3p Prostatic Neoplasms MNDR Database
hsa-miR-200c-3p psoriasis MNDR Database
hsa-miR-200c-3p pulmonary fibrosis MNDR Database
hsa-miR-200c-3p pulmonary tuberculosis MNDR Database
hsa-miR-200c-3p rectum adenocarcinoma MNDR Database
hsa-miR-200c-3p rectum cancer MNDR Database
hsa-miR-200c-3p regular astigmatism MNDR Database
hsa-miR-200c-3p relapsing-remitting multiple sclerosis MNDR Database
hsa-miR-200c-3p renal cell carcinoma MNDR Database
hsa-miR-200c-3p renal clear cell carcinoma MNDR Database
hsa-miR-200c-3p Reperfusion Injury MNDR Database
hsa-miR-200c-3p retinal degeneration MNDR Database
hsa-miR-200c-3p Retinal Neovascularization MNDR Database
hsa-miR-200c-3p retinoblastoma MNDR Database
hsa-miR-200c-3p rhabdomyosarcoma MNDR Database
hsa-miR-200c-3p rheumatoid arthritis MNDR Database
hsa-miR-200c-3p Rhinitis, Allergic, Perennial MNDR Database
hsa-miR-200c-3p salivary gland cancer MNDR Database
hsa-miR-200c-3p sarcoma MNDR Database
hsa-miR-200c-3p SARS Virus MNDR Database
hsa-miR-200c-3p schizophrenia MNDR Database
hsa-miR-200c-3p Sepsis MNDR Database
hsa-miR-200c-3p Sezary's disease MNDR Database
hsa-miR-200c-3p skin cancer MNDR Database
hsa-miR-200c-3p skin disease MNDR Database
hsa-miR-200c-3p skin melanoma MNDR Database
hsa-miR-200c-3p small cell carcinoma MNDR Database
hsa-miR-200c-3p Spinal Cord Injuries MNDR Database
hsa-miR-200c-3p squamous cell carcinoma MNDR Database
hsa-miR-200c-3p squamous cell neoplasm MNDR Database
hsa-miR-200c-3p stomach cancer MNDR Database
hsa-miR-200c-3p Stroke MNDR Database
hsa-miR-200c-3p syndrome MNDR Database
hsa-miR-200c-3p synovial sarcoma MNDR Database
hsa-miR-200c-3p systemic lupus erythematosus MNDR Database
hsa-miR-200c-3p systemic scleroderma MNDR Database
hsa-miR-200c-3p temporal lobe epilepsy MNDR Database
hsa-miR-200c-3p testicular cancer MNDR Database
hsa-miR-200c-3p testicular germ cell cancer MNDR Database
hsa-miR-200c-3p thoracic aortic aneurysm MNDR Database
hsa-miR-200c-3p thyroid cancer MNDR Database
hsa-miR-200c-3p thyroid carcinoma MNDR Database
hsa-miR-200c-3p tongue cancer MNDR Database
hsa-miR-200c-3p Toxoplasma MNDR Database
hsa-miR-200c-3p toxoplasmosis MNDR Database
hsa-miR-200c-3p triple-receptor negative breast cancer MNDR Database
hsa-miR-200c-3p Trophoblasts MNDR Database
hsa-miR-200c-3p type 1 diabetes mellitus MNDR Database
hsa-miR-200c-3p type 2 diabetes mellitus MNDR Database
hsa-miR-200c-3p ulcerative colitis MNDR Database
hsa-miR-200c-3p urinary bladder cancer MNDR Database
hsa-miR-200c-3p Urinary Bladder Neoplasms MNDR Database
hsa-miR-200c-3p uterine corpus endometrial carcinoma MNDR Database
hsa-miR-200c-3p Uterine Cervical Neoplasms MNDR Database
hsa-miR-200c-3p uterus leiomyosarcoma MNDR Database
hsa-miR-200c-3p vascular disease MNDR Database
hsa-miR-200c-3p viral hepatitis MNDR Database
hsa-miR-200c-3p Williams-Beuren syndrome MNDR Database
hsa-miR-200c-3p Wounds and Injuries MNDR Database
hsa-miR-200c-3p greig cephalopolysyndactyly syndrome eDGAR Database
hsa-miR-200c-3p hypothalamic hamartomas eDGAR Database
hsa-miR-200c-3p pallister-hall syndrome eDGAR Database
hsa-miR-200c-3p polydactyly, postaxial, type a1 eDGAR Database
hsa-miR-200c-3p polydactyly, preaxial iv eDGAR Database