Interaction ID
ncRI-40648924
Interaction Molecules
hsa-miR-518f-3p -- GNAI1
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T;motor cortex
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000127955
Description
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364).
| Pubmed ID | 24389009 | Journal | Neuron |
|---|---|---|---|
| Title | Transcriptome-wide discovery of microRNA binding sites in human brain. | ||
| Author | Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL | ||
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-518f-3p | Alzheimer's disease | MNDR Database |
| hsa-miR-518f-3p | arthritis | MNDR Database |
| hsa-miR-518f-3p | autosomal recessive disease | MNDR Database |
| hsa-miR-518f-3p | biliary tract cancer | MNDR Database |
| hsa-miR-518f-3p | bone disease | MNDR Database |
| hsa-miR-518f-3p | brain disease | MNDR Database |
| hsa-miR-518f-3p | breast cancer | MNDR Database |
| hsa-miR-518f-3p | Breast Neoplasms | MNDR Database |
| hsa-miR-518f-3p | cancer | MNDR Database |
| hsa-miR-518f-3p | carcinoma | MNDR Database |
| hsa-miR-518f-3p | colon cancer | MNDR Database |
| hsa-miR-518f-3p | colorectal cancer | MNDR Database |
| hsa-miR-518f-3p | dermatomyositis | MNDR Database |
| hsa-miR-518f-3p | diabetes mellitus | MNDR Database |
| hsa-miR-518f-3p | esophageal cancer | MNDR Database |
| hsa-miR-518f-3p | eye disease | MNDR Database |
| hsa-miR-518f-3p | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-518f-3p | Fetal Growth Retardation | MNDR Database |
| hsa-miR-518f-3p | follicular thyroid carcinoma | MNDR Database |
| hsa-miR-518f-3p | Friedreich ataxia | MNDR Database |
| hsa-miR-518f-3p | frontotemporal dementia | MNDR Database |
| hsa-miR-518f-3p | Gait Ataxia | MNDR Database |
| hsa-miR-518f-3p | Graft vs Host Disease | MNDR Database |
| hsa-miR-518f-3p | heart disease | MNDR Database |
| hsa-miR-518f-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-518f-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-518f-3p | HIV | MNDR Database |
| hsa-miR-518f-3p | hypersensitivity reaction type II disease | MNDR Database |
| hsa-miR-518f-3p | hypertension | MNDR Database |
| hsa-miR-518f-3p | inclusion body myositis | MNDR Database |
| hsa-miR-518f-3p | Infection | MNDR Database |
| hsa-miR-518f-3p | intellectual disability | MNDR Database |
| hsa-miR-518f-3p | kidney disease | MNDR Database |
| hsa-miR-518f-3p | leukemia | MNDR Database |
| hsa-miR-518f-3p | liver disease | MNDR Database |
| hsa-miR-518f-3p | lung adenocarcinoma | MNDR Database |
| hsa-miR-518f-3p | lung cancer | MNDR Database |
| hsa-miR-518f-3p | lung disease | MNDR Database |
| hsa-miR-518f-3p | lymphoma | MNDR Database |
| hsa-miR-518f-3p | malignant glioma | MNDR Database |
| hsa-miR-518f-3p | melanoma | MNDR Database |
| hsa-miR-518f-3p | myopathy | MNDR Database |
| hsa-miR-518f-3p | neurodegenerative disease | MNDR Database |
| hsa-miR-518f-3p | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-518f-3p | pancreatic cancer | MNDR Database |
| hsa-miR-518f-3p | pre-eclampsia | MNDR Database |
| hsa-miR-518f-3p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-518f-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-518f-3p | schizophrenia | MNDR Database |
| hsa-miR-518f-3p | skin disease | MNDR Database |
| hsa-miR-518f-3p | squamous cell carcinoma | MNDR Database |
| hsa-miR-518f-3p | stomach cancer | MNDR Database |
| hsa-miR-518f-3p | tonsil cancer | MNDR Database |
| hsa-miR-518f-3p | vascular disease | MNDR Database |