Interaction: ncRI-40648157

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Interaction Profile

Interaction ID

ncRI-40648157

Interaction Molecules

hsa-miR-1226-3p -- IVNS1ABP

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T;motor cortex

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-1226-3p

⇔

IVNS1ABP

Alias

-

Class

miRNA

miRBase id

MI0006313

Description

Homo sapiens miR-1226 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000116679

Description

Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).

Reference Information
Pubmed ID 24389009 Journal Neuron
Title Transcriptome-wide discovery of microRNA binding sites in human brain.
Author Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-1226-3p B-cell lymphoma MNDR Database
hsa-miR-1226-3p breast cancer MNDR Database
hsa-miR-1226-3p Breast Neoplasms MNDR Database
hsa-miR-1226-3p cancer MNDR Database
hsa-miR-1226-3p Carcinoma, Ductal, Breast MNDR Database
hsa-miR-1226-3p colon adenocarcinoma MNDR Database
hsa-miR-1226-3p colon cancer MNDR Database
hsa-miR-1226-3p colorectal cancer MNDR Database
hsa-miR-1226-3p esophageal cancer MNDR Database
hsa-miR-1226-3p familiar ovarian carcinoma MNDR Database
hsa-miR-1226-3p gastric adenocarcinoma MNDR Database
hsa-miR-1226-3p Glioblastoma MNDR Database
hsa-miR-1226-3p head and neck squamous cell carcinoma MNDR Database
hsa-miR-1226-3p hepatocellular carcinoma MNDR Database
hsa-miR-1226-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-1226-3p intracranial aneurysm MNDR Database
hsa-miR-1226-3p Liver Neoplasms MNDR Database
hsa-miR-1226-3p lung adenocarcinoma MNDR Database
hsa-miR-1226-3p lung small cell carcinoma MNDR Database
hsa-miR-1226-3p lung squamous cell carcinoma MNDR Database
hsa-miR-1226-3p lymphoma MNDR Database
hsa-miR-1226-3p malignant glioma MNDR Database
hsa-miR-1226-3p malignant pleural mesothelioma MNDR Database
hsa-miR-1226-3p melanoma MNDR Database
hsa-miR-1226-3p middle cerebral artery infarction MNDR Database
hsa-miR-1226-3p Moyamoya disease MNDR Database
hsa-miR-1226-3p multiple myeloma MNDR Database
hsa-miR-1226-3p nasopharynx carcinoma MNDR Database
hsa-miR-1226-3p nephroblastoma MNDR Database
hsa-miR-1226-3p oral squamous cell carcinoma MNDR Database
hsa-miR-1226-3p osteosarcoma MNDR Database
hsa-miR-1226-3p ovarian carcinoma MNDR Database
hsa-miR-1226-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-1226-3p pancreatic cancer MNDR Database
hsa-miR-1226-3p papillary renal cell carcinoma MNDR Database
hsa-miR-1226-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-1226-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-1226-3p rectum adenocarcinoma MNDR Database
hsa-miR-1226-3p relapsing-remitting multiple sclerosis MNDR Database
hsa-miR-1226-3p skin melanoma MNDR Database
hsa-miR-1226-3p stomach cancer MNDR Database
hsa-miR-1226-3p thyroid carcinoma MNDR Database
hsa-miR-1226-3p uterine corpus endometrial carcinoma MNDR Database