Interaction: ncRI-40646773

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Interaction Profile

Interaction ID

ncRI-40646773

Interaction Molecules

hsa-miR-374b-3p -- SLC16A1

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

TargetScan with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

HEK293T;T-REx-293T

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-374b-3p

⇔

SLC16A1

Alias

-

Class

miRNA

miRBase id

MI0005566

Description

Homo sapiens miR-374b stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000155380

Description

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

Reference Information
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-374b-3p Adenoviridae Infections MNDR Database
hsa-miR-374b-3p Adrenocortical Carcinoma MNDR Database
hsa-miR-374b-3p Alzheimer's disease MNDR Database
hsa-miR-374b-3p autosomal recessive disease MNDR Database
hsa-miR-374b-3p Barrett's adenocarcinoma MNDR Database
hsa-miR-374b-3p B-cell lymphoma MNDR Database
hsa-miR-374b-3p bladder urothelial carcinoma MNDR Database
hsa-miR-374b-3p bone disease MNDR Database
hsa-miR-374b-3p brain disease MNDR Database
hsa-miR-374b-3p breast cancer MNDR Database
hsa-miR-374b-3p Breast Neoplasms MNDR Database
hsa-miR-374b-3p cancer MNDR Database
hsa-miR-374b-3p carcinoma MNDR Database
hsa-miR-374b-3p Carcinoma, Ductal, Breast MNDR Database
hsa-miR-374b-3p Carcinoma, Renal Cell MNDR Database
hsa-miR-374b-3p cervical squamous cell carcinoma MNDR Database
hsa-miR-374b-3p cholangiocarcinoma MNDR Database
hsa-miR-374b-3p colon adenocarcinoma MNDR Database
hsa-miR-374b-3p colon cancer MNDR Database
hsa-miR-374b-3p colorectal cancer MNDR Database
hsa-miR-374b-3p diabetes mellitus MNDR Database
hsa-miR-374b-3p esophageal carcinoma MNDR Database
hsa-miR-374b-3p familiar ovarian carcinoma MNDR Database
hsa-miR-374b-3p fibromyalgia MNDR Database
hsa-miR-374b-3p gastric adenocarcinoma MNDR Database
hsa-miR-374b-3p Glioblastoma MNDR Database
hsa-miR-374b-3p Growth Hormone-Secreting Pituitary Adenoma MNDR Database
hsa-miR-374b-3p head and neck squamous cell carcinoma MNDR Database
hsa-miR-374b-3p hepatocellular carcinoma MNDR Database
hsa-miR-374b-3p Hodgkin's lymphoma MNDR Database
hsa-miR-374b-3p intellectual disability MNDR Database
hsa-miR-374b-3p intracranial aneurysm MNDR Database
hsa-miR-374b-3p Intracranial Hemorrhage, Hypertensive MNDR Database
hsa-miR-374b-3p kidney disease MNDR Database
hsa-miR-374b-3p leukemia MNDR Database
hsa-miR-374b-3p liposarcoma MNDR Database
hsa-miR-374b-3p lung adenocarcinoma MNDR Database
hsa-miR-374b-3p lung cancer MNDR Database
hsa-miR-374b-3p lung small cell carcinoma MNDR Database
hsa-miR-374b-3p lung squamous cell carcinoma MNDR Database
hsa-miR-374b-3p lymphoblastic lymphoma MNDR Database
hsa-miR-374b-3p lymphoma MNDR Database
hsa-miR-374b-3p male infertility MNDR Database
hsa-miR-374b-3p malignant glioma MNDR Database
hsa-miR-374b-3p malignant pleural mesothelioma MNDR Database
hsa-miR-374b-3p meningioma MNDR Database
hsa-miR-374b-3p multiple myeloma MNDR Database
hsa-miR-374b-3p Multiple Sclerosis, Chronic Progressive MNDR Database
hsa-miR-374b-3p nasopharynx carcinoma MNDR Database
hsa-miR-374b-3p nephroblastoma MNDR Database
hsa-miR-374b-3p neurodegenerative disease MNDR Database
hsa-miR-374b-3p oral squamous cell carcinoma MNDR Database
hsa-miR-374b-3p osteosarcoma MNDR Database
hsa-miR-374b-3p Ovarian Neoplasms MNDR Database
hsa-miR-374b-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-374b-3p pancreatic cancer MNDR Database
hsa-miR-374b-3p pancreatic ductal adenocarcinoma MNDR Database
hsa-miR-374b-3p papillary renal cell carcinoma MNDR Database
hsa-miR-374b-3p Parkinson's disease MNDR Database
hsa-miR-374b-3p pituitary adenoma MNDR Database
hsa-miR-374b-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-374b-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-374b-3p prolactinoma MNDR Database
hsa-miR-374b-3p prostate adenocarcinoma MNDR Database
hsa-miR-374b-3p Prostatic Neoplasms MNDR Database
hsa-miR-374b-3p rectum adenocarcinoma MNDR Database
hsa-miR-374b-3p relapsing-remitting multiple sclerosis MNDR Database
hsa-miR-374b-3p renal clear cell carcinoma MNDR Database
hsa-miR-374b-3p retinoblastoma MNDR Database
hsa-miR-374b-3p schizophrenia MNDR Database
hsa-miR-374b-3p stomach cancer MNDR Database
hsa-miR-374b-3p temporal lobe epilepsy MNDR Database
hsa-miR-374b-3p thyroid carcinoma MNDR Database
hsa-miR-374b-3p triple-receptor negative breast cancer MNDR Database
hsa-miR-374b-3p uterine corpus endometrial carcinoma MNDR Database
hsa-miR-374b-3p vascular disease MNDR Database
hsa-miR-374b-3p erythrocyte lactate transporter defect eDGAR Database
hsa-miR-374b-3p hyperinsulinemia hypoglycemia eDGAR Database
hsa-miR-374b-3p monocarboxylate transporter 1 deficiency eDGAR Database