Interaction: ncRI-40643395

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Interaction Profile

Interaction ID

ncRI-40643395

Interaction Molecules

hsa-miR-429 -- EPS8

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

TargetScan with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by TargetScan and miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-429

⇔

EPS8

Alias

-

Class

miRNA

miRBase id

MI0001641

Description

Homo sapiens miR-429 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000151491

Description

Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2- dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.

Reference Information
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-429 acute myeloid leukemia MNDR Database
hsa-miR-429 adenocarcinoma MNDR Database
hsa-miR-429 Alzheimer's disease MNDR Database
hsa-miR-429 autosomal recessive disease MNDR Database
hsa-miR-429 azoospermia MNDR Database
hsa-miR-429 Barrett's esophagus MNDR Database
hsa-miR-429 biliary tract cancer MNDR Database
hsa-miR-429 bladder urothelial carcinoma MNDR Database
hsa-miR-429 bone disease MNDR Database
hsa-miR-429 brain disease MNDR Database
hsa-miR-429 breast cancer MNDR Database
hsa-miR-429 Breast Neoplasms MNDR Database
hsa-miR-429 cancer MNDR Database
hsa-miR-429 carcinoma MNDR Database
hsa-miR-429 Carcinoma, Ductal, Breast MNDR Database
hsa-miR-429 Carcinoma, Non-Small-Cell Lung MNDR Database
hsa-miR-429 Carcinoma, Renal Cell MNDR Database
hsa-miR-429 cervical adenocarcinoma MNDR Database
hsa-miR-429 cervical squamous cell carcinoma MNDR Database
hsa-miR-429 cholangiocarcinoma MNDR Database
hsa-miR-429 colon adenocarcinoma MNDR Database
hsa-miR-429 colon cancer MNDR Database
hsa-miR-429 colorectal cancer MNDR Database
hsa-miR-429 Colorectal Neoplasms MNDR Database
hsa-miR-429 Crohn's disease MNDR Database
hsa-miR-429 diabetes mellitus MNDR Database
hsa-miR-429 dilated cardiomyopathy MNDR Database
hsa-miR-429 Ehrlich tumor carcinoma MNDR Database
hsa-miR-429 endometrial cancer MNDR Database
hsa-miR-429 endometriosis MNDR Database
hsa-miR-429 esophageal cancer MNDR Database
hsa-miR-429 eye disease MNDR Database
hsa-miR-429 gastric adenocarcinoma MNDR Database
hsa-miR-429 Gilles de la Tourette syndrome MNDR Database
hsa-miR-429 Glioblastoma MNDR Database
hsa-miR-429 gout MNDR Database
hsa-miR-429 head and neck cancer MNDR Database
hsa-miR-429 heart disease MNDR Database
hsa-miR-429 Heart Failure MNDR Database
hsa-miR-429 Helplessness, Learned MNDR Database
hsa-miR-429 hepatocellular carcinoma MNDR Database
hsa-miR-429 Her2-receptor positive breast cancer MNDR Database
hsa-miR-429 Hirschsprung's disease MNDR Database
hsa-miR-429 IgA glomerulonephritis MNDR Database
hsa-miR-429 intellectual disability MNDR Database
hsa-miR-429 intrahepatic cholangiocarcinoma MNDR Database
hsa-miR-429 kidney disease MNDR Database
hsa-miR-429 large cell neuroendocrine cancer MNDR Database
hsa-miR-429 leukemia MNDR Database
hsa-miR-429 liposarcoma MNDR Database
hsa-miR-429 Liver Neoplasms MNDR Database
hsa-miR-429 lung adenocarcinoma MNDR Database
hsa-miR-429 lung cancer MNDR Database
hsa-miR-429 lung disease MNDR Database
hsa-miR-429 lung small cell carcinoma MNDR Database
hsa-miR-429 lung squamous cell carcinoma MNDR Database
hsa-miR-429 Machado-Joseph disease MNDR Database
hsa-miR-429 malignant glioma MNDR Database
hsa-miR-429 melanoma MNDR Database
hsa-miR-429 mesenchymal cell neoplasm MNDR Database
hsa-miR-429 Mouth Neoplasms MNDR Database
hsa-miR-429 nasopharynx carcinoma MNDR Database
hsa-miR-429 Neoplasms MNDR Database
hsa-miR-429 nephroblastoma MNDR Database
hsa-miR-429 nephrosclerosis MNDR Database
hsa-miR-429 neurodegenerative disease MNDR Database
hsa-miR-429 oral squamous cell carcinoma MNDR Database
hsa-miR-429 osteosarcoma MNDR Database
hsa-miR-429 ovarian carcinoma MNDR Database
hsa-miR-429 Ovarian epithelial cancer MNDR Database
hsa-miR-429 Ovarian Neoplasms MNDR Database
hsa-miR-429 pancreatic cancer MNDR Database
hsa-miR-429 papillary renal cell carcinoma MNDR Database
hsa-miR-429 Parkinson's disease MNDR Database
hsa-miR-429 pediatric osteosarcoma MNDR Database
hsa-miR-429 pituitary adenoma MNDR Database
hsa-miR-429 progesterone-receptor negative breast cancer MNDR Database
hsa-miR-429 progesterone-receptor positive breast cancer MNDR Database
hsa-miR-429 Prostatic Neoplasms MNDR Database
hsa-miR-429 rectum adenocarcinoma MNDR Database
hsa-miR-429 renal cell carcinoma MNDR Database
hsa-miR-429 renal clear cell carcinoma MNDR Database
hsa-miR-429 retinoblastoma MNDR Database
hsa-miR-429 schizophrenia MNDR Database
hsa-miR-429 squamous cell carcinoma MNDR Database
hsa-miR-429 stomach cancer MNDR Database
hsa-miR-429 systemic lupus erythematosus MNDR Database
hsa-miR-429 temporal lobe epilepsy MNDR Database
hsa-miR-429 testicular germ cell cancer MNDR Database
hsa-miR-429 thyroid cancer MNDR Database
hsa-miR-429 thyroid carcinoma MNDR Database
hsa-miR-429 tonsil cancer MNDR Database
hsa-miR-429 triple-receptor negative breast cancer MNDR Database
hsa-miR-429 ulcerative colitis MNDR Database
hsa-miR-429 urinary bladder cancer MNDR Database
hsa-miR-429 Urinary Bladder Neoplasms MNDR Database
hsa-miR-429 uterine corpus endometrial carcinoma MNDR Database
hsa-miR-429 vascular disease MNDR Database
hsa-miR-429 deafness, autosomal recessive eDGAR Database