Interaction: ncRI-40642714

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Interaction Profile

Interaction ID

ncRI-40642714

Interaction Molecules

hsa-miR-561-3p -- UCHL1

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T;Cingulategyrus

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-561-3p

⇔

UCHL1

Alias

-

Class

miRNA

miRBase id

MI0003567

Description

Homo sapiens miR-561 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000154277

Description

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (PubMed:9774100, PubMed:8639624, PubMed:12408865, PubMed:23359680). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (PubMed:12408865).

Reference Information
Pubmed ID 24389009 Journal Neuron
Title Transcriptome-wide discovery of microRNA binding sites in human brain.
Author Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-561-3p arthritis MNDR Database
hsa-miR-561-3p autosomal recessive disease MNDR Database
hsa-miR-561-3p Barrett's adenocarcinoma MNDR Database
hsa-miR-561-3p bone disease MNDR Database
hsa-miR-561-3p brain disease MNDR Database
hsa-miR-561-3p breast cancer MNDR Database
hsa-miR-561-3p Breast Neoplasms MNDR Database
hsa-miR-561-3p cancer MNDR Database
hsa-miR-561-3p carcinoma MNDR Database
hsa-miR-561-3p Carcinoma, Renal Cell MNDR Database
hsa-miR-561-3p cholangiocarcinoma MNDR Database
hsa-miR-561-3p colorectal cancer MNDR Database
hsa-miR-561-3p diabetes mellitus MNDR Database
hsa-miR-561-3p eye disease MNDR Database
hsa-miR-561-3p familiar ovarian carcinoma MNDR Database
hsa-miR-561-3p Growth Hormone-Secreting Pituitary Adenoma MNDR Database
hsa-miR-561-3p heart disease MNDR Database
hsa-miR-561-3p hepatocellular carcinoma MNDR Database
hsa-miR-561-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-561-3p intellectual disability MNDR Database
hsa-miR-561-3p leukemia MNDR Database
hsa-miR-561-3p lung cancer MNDR Database
hsa-miR-561-3p lung disease MNDR Database
hsa-miR-561-3p lung squamous cell carcinoma MNDR Database
hsa-miR-561-3p lymphoma MNDR Database
hsa-miR-561-3p malignant glioma MNDR Database
hsa-miR-561-3p melanoma MNDR Database
hsa-miR-561-3p multiple myeloma MNDR Database
hsa-miR-561-3p nephroblastoma MNDR Database
hsa-miR-561-3p neurodegenerative disease MNDR Database
hsa-miR-561-3p non-Hodgkin lymphoma MNDR Database
hsa-miR-561-3p pancreatic cancer MNDR Database
hsa-miR-561-3p papillary renal cell carcinoma MNDR Database
hsa-miR-561-3p pituitary adenoma MNDR Database
hsa-miR-561-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-561-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-561-3p prostate adenocarcinoma MNDR Database
hsa-miR-561-3p rectum cancer MNDR Database
hsa-miR-561-3p renal cell carcinoma MNDR Database
hsa-miR-561-3p stomach cancer MNDR Database
hsa-miR-561-3p vascular disease MNDR Database
hsa-miR-561-3p neurodegeneration with optic atrophy, childhood-onset eDGAR Database
hsa-miR-561-3p parkinson disease eDGAR Database