Interaction ID
ncRI-40642267
Interaction Molecules
hsa-miR-577 -- STRAP
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000023734
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-577 | amyotrophic lateral sclerosis | MNDR Database |
| hsa-miR-577 | Barrett's adenocarcinoma | MNDR Database |
| hsa-miR-577 | breast cancer | MNDR Database |
| hsa-miR-577 | Breast Neoplasms | MNDR Database |
| hsa-miR-577 | cancer | MNDR Database |
| hsa-miR-577 | carcinoma | MNDR Database |
| hsa-miR-577 | Carcinoma, Renal Cell | MNDR Database |
| hsa-miR-577 | colon adenocarcinoma | MNDR Database |
| hsa-miR-577 | colon cancer | MNDR Database |
| hsa-miR-577 | colorectal cancer | MNDR Database |
| hsa-miR-577 | frontotemporal dementia | MNDR Database |
| hsa-miR-577 | gastric adenocarcinoma | MNDR Database |
| hsa-miR-577 | Glioblastoma | MNDR Database |
| hsa-miR-577 | head and neck squamous cell carcinoma | MNDR Database |
| hsa-miR-577 | hepatocellular carcinoma | MNDR Database |
| hsa-miR-577 | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-577 | Infection | MNDR Database |
| hsa-miR-577 | intrahepatic cholangiocarcinoma | MNDR Database |
| hsa-miR-577 | lung adenocarcinoma | MNDR Database |
| hsa-miR-577 | lung cancer | MNDR Database |
| hsa-miR-577 | lung squamous cell carcinoma | MNDR Database |
| hsa-miR-577 | malignant glioma | MNDR Database |
| hsa-miR-577 | melanoma | MNDR Database |
| hsa-miR-577 | nasopharynx carcinoma | MNDR Database |
| hsa-miR-577 | nephroblastoma | MNDR Database |
| hsa-miR-577 | pancreatic cancer | MNDR Database |
| hsa-miR-577 | papillary renal cell carcinoma | MNDR Database |
| hsa-miR-577 | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-577 | renal clear cell carcinoma | MNDR Database |
| hsa-miR-577 | stomach cancer | MNDR Database |
| hsa-miR-577 | thyroid carcinoma | MNDR Database |
| hsa-miR-577 | uterine corpus endometrial carcinoma | MNDR Database |
| hsa-miR-577 | vascular disease | MNDR Database |