Interaction ID
ncRI-40642061
Interaction Molecules
hsa-miR-92b-3p -- EP300
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Homo sapiens
Tissue or Cell Type
T-REx-293T
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSG00000100393
Description
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1- dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degragation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl- CoA) or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation or propionylation, respectively (PubMed:25818647, PubMed:17267393). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (E)-but-2-enoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097).
| Pubmed ID | 29273203 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets. | ||
| Author | Li Y, Estep JA, Karginov FV | ||
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-miR-92b-3p | acute myeloid leukemia | MNDR Database |
| hsa-miR-92b-3p | Alzheimer's disease | MNDR Database |
| hsa-miR-92b-3p | arthritis | MNDR Database |
| hsa-miR-92b-3p | asthma | MNDR Database |
| hsa-miR-92b-3p | astrocytoma | MNDR Database |
| hsa-miR-92b-3p | autosomal recessive disease | MNDR Database |
| hsa-miR-92b-3p | biliary tract cancer | MNDR Database |
| hsa-miR-92b-3p | bladder urothelial carcinoma | MNDR Database |
| hsa-miR-92b-3p | bone disease | MNDR Database |
| hsa-miR-92b-3p | brain cancer | MNDR Database |
| hsa-miR-92b-3p | brain disease | MNDR Database |
| hsa-miR-92b-3p | breast cancer | MNDR Database |
| hsa-miR-92b-3p | Breast Neoplasms | MNDR Database |
| hsa-miR-92b-3p | cancer | MNDR Database |
| hsa-miR-92b-3p | carcinoma | MNDR Database |
| hsa-miR-92b-3p | Carcinoma, Ductal, Breast | MNDR Database |
| hsa-miR-92b-3p | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| hsa-miR-92b-3p | Carcinoma, Renal Cell | MNDR Database |
| hsa-miR-92b-3p | cervical adenocarcinoma | MNDR Database |
| hsa-miR-92b-3p | cervical squamous cell carcinoma | MNDR Database |
| hsa-miR-92b-3p | cholangiocarcinoma | MNDR Database |
| hsa-miR-92b-3p | chordoma | MNDR Database |
| hsa-miR-92b-3p | colon adenocarcinoma | MNDR Database |
| hsa-miR-92b-3p | colon cancer | MNDR Database |
| hsa-miR-92b-3p | colorectal cancer | MNDR Database |
| hsa-miR-92b-3p | diabetes mellitus | MNDR Database |
| hsa-miR-92b-3p | Down syndrome | MNDR Database |
| hsa-miR-92b-3p | esophageal cancer | MNDR Database |
| hsa-miR-92b-3p | eye disease | MNDR Database |
| hsa-miR-92b-3p | familiar ovarian carcinoma | MNDR Database |
| hsa-miR-92b-3p | Glioblastoma | MNDR Database |
| hsa-miR-92b-3p | Graves' disease | MNDR Database |
| hsa-miR-92b-3p | head and neck cancer | MNDR Database |
| hsa-miR-92b-3p | head and neck squamous cell carcinoma | MNDR Database |
| hsa-miR-92b-3p | heart disease | MNDR Database |
| hsa-miR-92b-3p | Heart Failure | MNDR Database |
| hsa-miR-92b-3p | hepatocellular carcinoma | MNDR Database |
| hsa-miR-92b-3p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-miR-92b-3p | Huntington's disease | MNDR Database |
| hsa-miR-92b-3p | hypersensitivity reaction type II disease | MNDR Database |
| hsa-miR-92b-3p | hypertension | MNDR Database |
| hsa-miR-92b-3p | intellectual disability | MNDR Database |
| hsa-miR-92b-3p | interstitial lung disease | MNDR Database |
| hsa-miR-92b-3p | kidney disease | MNDR Database |
| hsa-miR-92b-3p | leukemia | MNDR Database |
| hsa-miR-92b-3p | liposarcoma | MNDR Database |
| hsa-miR-92b-3p | liver disease | MNDR Database |
| hsa-miR-92b-3p | Liver Neoplasms | MNDR Database |
| hsa-miR-92b-3p | lung adenocarcinoma | MNDR Database |
| hsa-miR-92b-3p | lung cancer | MNDR Database |
| hsa-miR-92b-3p | lung disease | MNDR Database |
| hsa-miR-92b-3p | lupus nephritis | MNDR Database |
| hsa-miR-92b-3p | lymphoma | MNDR Database |
| hsa-miR-92b-3p | malignant glioma | MNDR Database |
| hsa-miR-92b-3p | malignant pleural mesothelioma | MNDR Database |
| hsa-miR-92b-3p | medulloblastoma | MNDR Database |
| hsa-miR-92b-3p | melanoma | MNDR Database |
| hsa-miR-92b-3p | middle cerebral artery infarction | MNDR Database |
| hsa-miR-92b-3p | Myasthenia Gravis, Autoimmune, Experimental | MNDR Database |
| hsa-miR-92b-3p | myopathy | MNDR Database |
| hsa-miR-92b-3p | nasopharynx carcinoma | MNDR Database |
| hsa-miR-92b-3p | Neoplasms | MNDR Database |
| hsa-miR-92b-3p | nephroblastoma | MNDR Database |
| hsa-miR-92b-3p | neuroblastoma | MNDR Database |
| hsa-miR-92b-3p | neurodegenerative disease | MNDR Database |
| hsa-miR-92b-3p | neuromyelitis optica | MNDR Database |
| hsa-miR-92b-3p | Non-alcoholic Fatty Liver Disease | MNDR Database |
| hsa-miR-92b-3p | oral squamous cell carcinoma | MNDR Database |
| hsa-miR-92b-3p | osteosarcoma | MNDR Database |
| hsa-miR-92b-3p | ovarian carcinoma | MNDR Database |
| hsa-miR-92b-3p | Ovarian Neoplasms | MNDR Database |
| hsa-miR-92b-3p | pancreatic adenocarcinoma | MNDR Database |
| hsa-miR-92b-3p | pancreatic cancer | MNDR Database |
| hsa-miR-92b-3p | pancreatic ductal adenocarcinoma | MNDR Database |
| hsa-miR-92b-3p | papillary renal cell carcinoma | MNDR Database |
| hsa-miR-92b-3p | Parkinson's disease | MNDR Database |
| hsa-miR-92b-3p | polycystic ovary syndrome | MNDR Database |
| hsa-miR-92b-3p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-miR-92b-3p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-miR-92b-3p | progressive supranuclear palsy | MNDR Database |
| hsa-miR-92b-3p | Pseudorabies | MNDR Database |
| hsa-miR-92b-3p | rectum adenocarcinoma | MNDR Database |
| hsa-miR-92b-3p | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-miR-92b-3p | renal clear cell carcinoma | MNDR Database |
| hsa-miR-92b-3p | retinoblastoma | MNDR Database |
| hsa-miR-92b-3p | schizophrenia | MNDR Database |
| hsa-miR-92b-3p | skin disease | MNDR Database |
| hsa-miR-92b-3p | squamous cell carcinoma | MNDR Database |
| hsa-miR-92b-3p | squamous cell neoplasm | MNDR Database |
| hsa-miR-92b-3p | stomach cancer | MNDR Database |
| hsa-miR-92b-3p | Stroke, Lacunar | MNDR Database |
| hsa-miR-92b-3p | Subarachnoid Hemorrhage, Traumatic | MNDR Database |
| hsa-miR-92b-3p | synovial sarcoma | MNDR Database |
| hsa-miR-92b-3p | temporal lobe epilepsy | MNDR Database |
| hsa-miR-92b-3p | thyroid cancer | MNDR Database |
| hsa-miR-92b-3p | thyroid carcinoma | MNDR Database |
| hsa-miR-92b-3p | uterine corpus endometrial carcinoma | MNDR Database |
| hsa-miR-92b-3p | vascular disease | MNDR Database |
| hsa-miR-92b-3p | colorectal cancer | eDGAR Database |
| hsa-miR-92b-3p | rubinstein-taybi syndrome | eDGAR Database |