Interaction: ncRI-40641927

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Interaction Profile

Interaction ID

ncRI-40641927

Interaction Molecules

hsa-miR-495-3p -- USP28

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T;HEK293S

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-495-3p

⇔

USP28

Alias

-

Class

miRNA

miRBase id

MI0003135

Description

Homo sapiens miR-495 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000048028

Description

Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306).

Reference Information
Pubmed ID 23824327 Journal Genes & development
Title Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
Author Karginov FV, Hannon GJ
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-495-3p adrenocortical carcinoma MNDR Database
hsa-miR-495-3p AIDS Dementia Complex MNDR Database
hsa-miR-495-3p Alzheimer's disease MNDR Database
hsa-miR-495-3p amyotrophic lateral sclerosis MNDR Database
hsa-miR-495-3p autosomal recessive limb-girdle muscular dystrophy type 2A MNDR Database
hsa-miR-495-3p autosomal recessive limb-girdle muscular dystrophy type 2B MNDR Database
hsa-miR-495-3p bladder urothelial carcinoma MNDR Database
hsa-miR-495-3p bone disease MNDR Database
hsa-miR-495-3p brain disease MNDR Database
hsa-miR-495-3p breast cancer MNDR Database
hsa-miR-495-3p Breast Neoplasms MNDR Database
hsa-miR-495-3p cancer MNDR Database
hsa-miR-495-3p carcinoma MNDR Database
hsa-miR-495-3p Carcinoma, Ductal, Breast MNDR Database
hsa-miR-495-3p Carcinoma, Non-Small-Cell Lung MNDR Database
hsa-miR-495-3p Carcinoma, Renal Cell MNDR Database
hsa-miR-495-3p cervical squamous cell carcinoma MNDR Database
hsa-miR-495-3p cholangiocarcinoma MNDR Database
hsa-miR-495-3p colon cancer MNDR Database
hsa-miR-495-3p colorectal cancer MNDR Database
hsa-miR-495-3p coronary artery disease MNDR Database
hsa-miR-495-3p dermatomyositis MNDR Database
hsa-miR-495-3p diabetes mellitus MNDR Database
hsa-miR-495-3p dilated cardiomyopathy MNDR Database
hsa-miR-495-3p distal muscular dystrophy MNDR Database
hsa-miR-495-3p Duchenne muscular dystrophy MNDR Database
hsa-miR-495-3p endometrial cancer MNDR Database
hsa-miR-495-3p esophageal carcinoma MNDR Database
hsa-miR-495-3p eye disease MNDR Database
hsa-miR-495-3p familiar ovarian carcinoma MNDR Database
hsa-miR-495-3p gastric adenocarcinoma MNDR Database
hsa-miR-495-3p Glioblastoma MNDR Database
hsa-miR-495-3p head and neck squamous cell carcinoma MNDR Database
hsa-miR-495-3p heart disease MNDR Database
hsa-miR-495-3p hepatocellular carcinoma MNDR Database
hsa-miR-495-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-495-3p Huntington's disease MNDR Database
hsa-miR-495-3p hypersensitivity reaction type II disease MNDR Database
hsa-miR-495-3p intellectual disability MNDR Database
hsa-miR-495-3p leukemia MNDR Database
hsa-miR-495-3p lung cancer MNDR Database
hsa-miR-495-3p lung small cell carcinoma MNDR Database
hsa-miR-495-3p malignant glioma MNDR Database
hsa-miR-495-3p medulloblastoma MNDR Database
hsa-miR-495-3p melanoma MNDR Database
hsa-miR-495-3p Muscular Disorders, Atrophic MNDR Database
hsa-miR-495-3p nasopharynx carcinoma MNDR Database
hsa-miR-495-3p nemaline myopathy MNDR Database
hsa-miR-495-3p nephroblastoma MNDR Database
hsa-miR-495-3p neurodegenerative disease MNDR Database
hsa-miR-495-3p oral squamous cell carcinoma MNDR Database
hsa-miR-495-3p osteosarcoma MNDR Database
hsa-miR-495-3p ovarian carcinoma MNDR Database
hsa-miR-495-3p Ovarian epithelial cancer MNDR Database
hsa-miR-495-3p Ovarian Neoplasms MNDR Database
hsa-miR-495-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-495-3p pancreatic cancer MNDR Database
hsa-miR-495-3p papillary renal cell carcinoma MNDR Database
hsa-miR-495-3p periodontitis MNDR Database
hsa-miR-495-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-495-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-495-3p prostate adenocarcinoma MNDR Database
hsa-miR-495-3p renal cell carcinoma MNDR Database
hsa-miR-495-3p renal clear cell carcinoma MNDR Database
hsa-miR-495-3p salivary gland cancer MNDR Database
hsa-miR-495-3p squamous cell carcinoma MNDR Database
hsa-miR-495-3p stomach cancer MNDR Database
hsa-miR-495-3p synovial sarcoma MNDR Database
hsa-miR-495-3p temporal lobe epilepsy MNDR Database
hsa-miR-495-3p thyroid cancer MNDR Database
hsa-miR-495-3p thyroid carcinoma MNDR Database
hsa-miR-495-3p urinary bladder cancer MNDR Database
hsa-miR-495-3p uterine corpus endometrial carcinoma MNDR Database
hsa-miR-495-3p vascular disease MNDR Database