Interaction: ncRI-40639516

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Interaction Profile

Interaction ID

ncRI-40639516

Interaction Molecules

hsa-miR-520a-3p -- SMC1A

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

HEK293T;T-REx-293T;HEK293S

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-520a-3p

⇔

SMC1A

Alias

-

Class

miRNA

miRBase id

MI0003149

Description

Homo sapiens miR-520a stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000072501

Description

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Reference Information
Pubmed ID 23824327 Journal Genes & development
Title Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.
Author Karginov FV, Hannon GJ
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-520a-3p adenocarcinoma MNDR Database
hsa-miR-520a-3p adenoma MNDR Database
hsa-miR-520a-3p Alzheimer's disease MNDR Database
hsa-miR-520a-3p amyotrophic lateral sclerosis MNDR Database
hsa-miR-520a-3p arthritis MNDR Database
hsa-miR-520a-3p asthma MNDR Database
hsa-miR-520a-3p atherosclerosis MNDR Database
hsa-miR-520a-3p autosomal recessive disease MNDR Database
hsa-miR-520a-3p bone disease MNDR Database
hsa-miR-520a-3p brain disease MNDR Database
hsa-miR-520a-3p breast cancer MNDR Database
hsa-miR-520a-3p Breast Neoplasms MNDR Database
hsa-miR-520a-3p cancer MNDR Database
hsa-miR-520a-3p carcinoma MNDR Database
hsa-miR-520a-3p Carcinoma, Non-Small-Cell Lung MNDR Database
hsa-miR-520a-3p cholangiocarcinoma MNDR Database
hsa-miR-520a-3p colorectal cancer MNDR Database
hsa-miR-520a-3p diabetes mellitus MNDR Database
hsa-miR-520a-3p embryonal cancer MNDR Database
hsa-miR-520a-3p endometriosis MNDR Database
hsa-miR-520a-3p eye disease MNDR Database
hsa-miR-520a-3p familiar ovarian carcinoma MNDR Database
hsa-miR-520a-3p Fetal Growth Retardation MNDR Database
hsa-miR-520a-3p gout MNDR Database
hsa-miR-520a-3p heart disease MNDR Database
hsa-miR-520a-3p Heart Failure MNDR Database
hsa-miR-520a-3p hepatocellular carcinoma MNDR Database
hsa-miR-520a-3p Her2-receptor positive breast cancer MNDR Database
hsa-miR-520a-3p Hodgkin's lymphoma MNDR Database
hsa-miR-520a-3p hypersensitivity reaction type II disease MNDR Database
hsa-miR-520a-3p hypertension MNDR Database
hsa-miR-520a-3p intellectual disability MNDR Database
hsa-miR-520a-3p kidney disease MNDR Database
hsa-miR-520a-3p leukemia MNDR Database
hsa-miR-520a-3p liposarcoma MNDR Database
hsa-miR-520a-3p liver disease MNDR Database
hsa-miR-520a-3p lung cancer MNDR Database
hsa-miR-520a-3p lung disease MNDR Database
hsa-miR-520a-3p lung squamous cell carcinoma MNDR Database
hsa-miR-520a-3p lymphoma MNDR Database
hsa-miR-520a-3p malignant glioma MNDR Database
hsa-miR-520a-3p melanoma MNDR Database
hsa-miR-520a-3p Multiple Sclerosis, Chronic Progressive MNDR Database
hsa-miR-520a-3p myocardial infarction MNDR Database
hsa-miR-520a-3p myopathy MNDR Database
hsa-miR-520a-3p nasopharynx carcinoma MNDR Database
hsa-miR-520a-3p nephroblastoma MNDR Database
hsa-miR-520a-3p neurodegenerative disease MNDR Database
hsa-miR-520a-3p pancreatic adenocarcinoma MNDR Database
hsa-miR-520a-3p pancreatic cancer MNDR Database
hsa-miR-520a-3p pancreatic ductal adenocarcinoma MNDR Database
hsa-miR-520a-3p pre-eclampsia MNDR Database
hsa-miR-520a-3p progesterone-receptor negative breast cancer MNDR Database
hsa-miR-520a-3p progesterone-receptor positive breast cancer MNDR Database
hsa-miR-520a-3p relapsing-remitting multiple sclerosis MNDR Database
hsa-miR-520a-3p retinal degeneration MNDR Database
hsa-miR-520a-3p skin disease MNDR Database
hsa-miR-520a-3p squamous cell carcinoma MNDR Database
hsa-miR-520a-3p stomach cancer MNDR Database
hsa-miR-520a-3p tonsil cancer MNDR Database
hsa-miR-520a-3p vascular disease MNDR Database
hsa-miR-520a-3p cornelia de lange syndrome eDGAR Database
hsa-miR-520a-3p wiedemann-steiner syndrome eDGAR Database