Interaction: ncRI-40639422

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Interaction Profile

Interaction ID

ncRI-40639422

Interaction Molecules

hsa-miR-608 -- ARPC2

Interaction Level

RNA-RNA

Interaction Class

binding

Data Source

miRanda with Ago CLIP data

Tags

Organism

Homo sapiens

Tissue or Cell Type

T-REx-293T

Experiment

AGO CLIP

Description

Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset

Molecule Profile

hsa-miR-608

⇔

ARPC2

Alias

-

Class

miRNA

miRBase id

MI0003621

Description

Homo sapiens miR-608 stem-loop

Alias

-

Class

mRNA

Ensembl id

ENSG00000163466

Description

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Reference Information
Pubmed ID 29273203 Journal Journal of molecular biology
Title Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Author Li Y, Estep JA, Karginov FV
Network View
Disease Annotation
Molecule Disease Data Source
hsa-miR-608 adenocarcinoma MNDR Database
hsa-miR-608 Alzheimer's disease MNDR Database
hsa-miR-608 atherosclerosis MNDR Database
hsa-miR-608 autosomal recessive disease MNDR Database
hsa-miR-608 bone disease MNDR Database
hsa-miR-608 brain disease MNDR Database
hsa-miR-608 breast cancer MNDR Database
hsa-miR-608 Breast Neoplasms MNDR Database
hsa-miR-608 cancer MNDR Database
hsa-miR-608 carcinoma MNDR Database
hsa-miR-608 cholangiocarcinoma MNDR Database
hsa-miR-608 chordoma MNDR Database
hsa-miR-608 colon cancer MNDR Database
hsa-miR-608 colorectal cancer MNDR Database
hsa-miR-608 diabetes mellitus MNDR Database
hsa-miR-608 embryonal cancer MNDR Database
hsa-miR-608 eye disease MNDR Database
hsa-miR-608 heart disease MNDR Database
hsa-miR-608 hepatocellular carcinoma MNDR Database
hsa-miR-608 Her2-receptor positive breast cancer MNDR Database
hsa-miR-608 hypersensitivity reaction type II disease MNDR Database
hsa-miR-608 hypertension MNDR Database
hsa-miR-608 intellectual disability MNDR Database
hsa-miR-608 Kaposi's sarcoma MNDR Database
hsa-miR-608 kidney disease MNDR Database
hsa-miR-608 leukemia MNDR Database
hsa-miR-608 Liver Neoplasms MNDR Database
hsa-miR-608 lung cancer MNDR Database
hsa-miR-608 lung disease MNDR Database
hsa-miR-608 Lupus Vulgaris MNDR Database
hsa-miR-608 lymphoma MNDR Database
hsa-miR-608 malignant glioma MNDR Database
hsa-miR-608 melanoma MNDR Database
hsa-miR-608 meningioma MNDR Database
hsa-miR-608 multiple myeloma MNDR Database
hsa-miR-608 myopathy MNDR Database
hsa-miR-608 nasopharynx carcinoma MNDR Database
hsa-miR-608 neurodegenerative disease MNDR Database
hsa-miR-608 oral squamous cell carcinoma MNDR Database
hsa-miR-608 Ovarian Neoplasms MNDR Database
hsa-miR-608 pancreatic cancer MNDR Database
hsa-miR-608 pancreatic ductal adenocarcinoma MNDR Database
hsa-miR-608 Peripheral Nervous System Diseases MNDR Database
hsa-miR-608 progesterone-receptor negative breast cancer MNDR Database
hsa-miR-608 progesterone-receptor positive breast cancer MNDR Database
hsa-miR-608 Prostatic Neoplasms MNDR Database
hsa-miR-608 schizophrenia MNDR Database
hsa-miR-608 skin disease MNDR Database
hsa-miR-608 stomach cancer MNDR Database
hsa-miR-608 vascular disease MNDR Database