Interaction Profile
Interaction ID
ncRI-40583701
Interaction Molecules
RP11-267C16.1 -- AGO4
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
C666
Experiment
CLIP
Description
derived from CLIP-seq dataset
Molecule Profile
Alias
-
Class
protein
UniProt id
Description
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 8662553 | chr18:48878643-48878657 | - |
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| RP11-267C16.1 | Alzheimer's disease | MNDR Database |
| RP11-267C16.1 | breast cancer | MNDR Database |
| RP11-267C16.1 | cancer | MNDR Database |
| RP11-267C16.1 | colorectal cancer | MNDR Database |
| RP11-267C16.1 | hepatocellular carcinoma | MNDR Database |
| RP11-267C16.1 | Huntington's disease | MNDR Database |
| RP11-267C16.1 | lung cancer | MNDR Database |
| RP11-267C16.1 | lymphoma | MNDR Database |
| RP11-267C16.1 | melanoma | MNDR Database |
| RP11-267C16.1 | nephroblastoma | MNDR Database |
| RP11-267C16.1 | neuroblastoma | MNDR Database |
| RP11-267C16.1 | Ovarian Neoplasms | MNDR Database |
| RP11-267C16.1 | pancreatic ductal adenocarcinoma | MNDR Database |
| RP11-267C16.1 | papillary thyroid carcinoma | MNDR Database |
| RP11-267C16.1 | Prostatic Neoplasms | MNDR Database |
| RP11-267C16.1 | schizophrenia | MNDR Database |
| RP11-267C16.1 | type 2 diabetes mellitus | MNDR Database |