Interaction Profile
Interaction ID
ncRI-40571229
Interaction Molecules
A330023F24Rik -- RFOX2
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Mus musculus
Tissue or Cell Type
Cardiomyocyte
Experiment
CLIP
Description
derived from CLIP-seq dataset
Molecule Profile
Alias
-
Class
protein
UniProt id
Description
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity).
Reference Information
| Pubmed ID | 25753418 | Journal | Cell reports |
|---|---|---|---|
| Title | Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure. | ||
| Author | Wei C, Qiu J, Zhou Y, Xue Y, Hu J, Ouyang K, Banerjee I, Zhang C, Chen B, Li H, Chen J, Song LS, Fu XD | ||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 8931149 | chr1:196804400-196804450 | 1.000000 |
| 8931180 | chr1:196816100-196816150 | 0.020960 |
| 8931181 | chr1:196816200-196816250 | 0.003640 |
| 8931182 | chr1:196816300-196816350 | 0.005940 |
| 8931183 | chr1:196816650-196816700 | 0.003480 |
| 8931188 | chr1:196817850-196817900 | 0.021660 |
| 8931196 | chr1:196819300-196819350 | 0.004380 |
| 8931215 | chr1:196826600-196826650 | 0.001340 |
| 8931217 | chr1:196827450-196827500 | 0.193440 |
| 8931240 | chr1:196832600-196832650 | 0.027220 |
| 8931265 | chr1:196838600-196838650 | 0.132340 |
| 8931274 | chr1:196843700-196843750 | 0.996460 |
| 8931275 | chr1:196844050-196844100 | 0.333560 |
| 8931276 | chr1:196844200-196844250 | 0.989840 |
| 8931291 | chr1:196848000-196848050 | 0.775300 |
| 8931296 | chr1:196848800-196848850 | 0.000720 |
| 8931305 | chr1:196856900-196856950 | 0.001480 |
| 8931306 | chr1:196857250-196857300 | 0.001280 |
| 8931316 | chr1:196858200-196858250 | 0.738320 |
| 8931329 | chr1:196860350-196860400 | 0.116860 |
| 8931331 | chr1:196860600-196860650 | 0.017360 |
| 8931332 | chr1:196860700-196860800 | 0.001110 |
| 8931334 | chr1:196861650-196861700 | 0.000460 |
| 8931356 | chr1:196863750-196863800 | 0.999960 |
Network View