Interaction ID
ncRI-40565360
Interaction Molecules
Gm11574 -- PSPC1
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Mus musculus
Tissue or Cell Type
ESC
Experiment
CLIP
Description
derived from CLIP-seq dataset
Alias
-
Class
protein
UniProt id
Description
Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
| Pubmed ID | 29483655 | Journal | Nature genetics |
|---|---|---|---|
| Title | RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells. | ||
| Author | Guallar D, Bi X, Pardavila JA, Huang X, Saenz C, Shi X, Zhou H, Faiola F, Ding J, Haruehanroengra P, Yang F, Li D, Sanchez-Priego C, Saunders A, Pan F, Valdes VJ, Kelley K, Blanco MG, Chen L, Wang H, Sheng J, Xu M, Fidalgo M, Shen X, Wang J | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 8937913 | chr11:96910200-96910600 | - |