Interaction Profile
Interaction ID
ncRI-40263038
Interaction Molecules
Gm16542 -- Tdp43
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Mus musculus
Tissue or Cell Type
mouse brain
Experiment
CLIP-Seq
Description
Mouse CLIPseq Tdp43.
Molecule Profile
Alias
TDP-43
Class
protein
UniProt id
Description
DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division (By similarity).
Reference Information
| Pubmed ID | 23023293 | Journal | Nature neuroscience |
|---|---|---|---|
| Title | Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. | ||
| Author | Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW, Yeo GW | ||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 7358999 | chr14:11573100-11573135 | 0.124457142857 |
| 7359000 | chr14:11583671-11583700 | 0.027 |
| 7359001 | chr14:11590300-11590324 | 0.0880833333333 |
Network View