Interaction ID
ncRI-40155484
Interaction Molecules
RP5-930J4.4 -- UPF1
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293
Experiment
PAR-CLIP
Description
PAR-CLIP of UPF1 reveals that MOV10 and UPF1 bind to RNA in close proximity.
Alias
RENT1
Class
protein
UniProt id
Description
RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with th
| Pubmed ID | 24726324 | Journal | Molecular cell |
|---|---|---|---|
| Title | MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. | ||
| Author | Gregersen LH, Schueler M, Munschauer M, Mastrobuoni G, Chen W, Kempa S, Dieterich C, Landthaler M | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 3707264 | chr1:21069570-21069571 | 0.057 |