Interaction ID
ncRI-40122745
Interaction Molecules
RP5-1011O1.2 -- TARBP2
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
MDA-LM2
Experiment
HITS-CLIP
Description
Identify TARBP2 binding sites on endogenous RNA.
Alias
-
Class
protein
UniProt id
Description
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in
| Pubmed ID | 25043050 | Journal | Nature |
|---|---|---|---|
| Title | Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins. | ||
| Author | Goodarzi H, Zhang S, Buss CG, Fish L, Tavazoie S, Tavazoie SF | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 4090505 | chr1:192495440-192495676 | 0.0581313559322 |
| Molecule | Disease | Data Source |
|---|---|---|
| RP5-1011O1.2 | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| RP5-1011O1.2 | lymphoma | MNDR Database |
| RP5-1011O1.2 | malignant glioma | MNDR Database |
| RP5-1011O1.2 | stomach cancer | MNDR Database |
| RP5-1011O1.2 | thyroid cancer | MNDR Database |
| RP5-1011O1.2 | Urinary Bladder Neoplasms | MNDR Database |
| RP5-1011O1.2 | Uterine Cervical Neoplasms | MNDR Database |