Interaction ID
ncRI-40118419
Interaction Molecules
GPBP1L1 -- hnRNPC
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HeLa
Experiment
iCLIP
Description
Quantitative iCLIP reveals genome-wide competition of hnRNP C and U2AF65;CLIPseq data were analysed by CLIPdb
Alias
HNRPC
Class
protein
UniProt id
Description
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-2
| Pubmed ID | 23374342 | Journal | Cell |
|---|---|---|---|
| Title | Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. | ||
| Author | Zarnack K, König J, Tajnik M, Martincorena I, Eustermann S, Stévant I, Reyes A, Anders S, Luscombe NM, Ule J | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 375142 | chr1:46126281-46126321 | 0.1396 |
| 375159 | chr1:46126441-46126481 | 0.2892 |
| 375341 | chr1:46135161-46135181 | 0.09255 |
| 375376 | chr1:46139481-46139501 | 0.0111 |
| 375413 | chr1:46142521-46142541 | 0.1712 |
| 375415 | chr1:46142961-46143001 | 0.012375 |
| 375418 | chr1:46143241-46143261 | 0.07475 |
| 375653 | chr1:46149561-46149581 | 0.2013 |
| 375785 | chr1:46150701-46150721 | 0.0341 |