Interaction ID
ncRI-40118396
Interaction Molecules
RBBP4 -- hnRNPC
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HeLa
Experiment
iCLIP
Description
Quantitative iCLIP reveals genome-wide competition of hnRNP C and U2AF65;CLIPseq data were analysed by CLIPdb
Alias
HNRPC
Class
protein
UniProt id
Description
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-2
| Pubmed ID | 23374342 | Journal | Cell |
|---|---|---|---|
| Title | Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. | ||
| Author | Zarnack K, König J, Tajnik M, Martincorena I, Eustermann S, Stévant I, Reyes A, Anders S, Luscombe NM, Ule J | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 307748 | chr1:33118141-33118161 | 0.0514 |
| 307751 | chr1:33118301-33118341 | 0.054675 |
| 307762 | chr1:33119261-33119281 | 0.0887 |
| 307791 | chr1:33123461-33123481 | 0.00335 |
| 307793 | chr1:33123901-33123921 | 0.13535 |
| 307816 | chr1:33125461-33125481 | 0.2067 |
| 307820 | chr1:33125721-33125741 | 0.0133 |
| 307824 | chr1:33126181-33126201 | 0.12845 |
| 307825 | chr1:33126201-33126221 | 0.13315 |
| 307833 | chr1:33126401-33126421 | 0.04005 |
| 307835 | chr1:33126721-33126741 | 0.26355 |
| 307837 | chr1:33126901-33126921 | 0.01885 |
| 307838 | chr1:33127501-33127521 | 0.0246 |
| 307841 | chr1:33127801-33127821 | 0.08905 |
| 307880 | chr1:33129181-33129201 | 0.03025 |
| 307881 | chr1:33129521-33129561 | 0.045 |
| 307890 | chr1:33130341-33130361 | 0.01635 |