Interaction ID
ncRI-40118395
Interaction Molecules
ZBTB8OS -- hnRNPC
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HeLa
Experiment
iCLIP
Description
Quantitative iCLIP reveals genome-wide competition of hnRNP C and U2AF65;CLIPseq data were analysed by CLIPdb
Alias
HNRPC
Class
protein
UniProt id
Description
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-2
| Pubmed ID | 23374342 | Journal | Cell |
|---|---|---|---|
| Title | Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. | ||
| Author | Zarnack K, König J, Tajnik M, Martincorena I, Eustermann S, Stévant I, Reyes A, Anders S, Luscombe NM, Ule J | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 307613 | chr1:33093901-33093921 | 0.01245 |
| 307615 | chr1:33094481-33094501 | 0.00355 |
| 307625 | chr1:33096401-33096421 | 0.00365 |
| 307639 | chr1:33098261-33098281 | 0.00515 |
| 307647 | chr1:33098921-33098941 | 0.0009 |
| 307670 | chr1:33103121-33103141 | 0.36105 |