Interaction ID
ncRI-40118360
Interaction Molecules
RPL22 -- hnRNPC
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HeLa
Experiment
iCLIP
Description
Quantitative iCLIP reveals genome-wide competition of hnRNP C and U2AF65;CLIPseq data were analysed by CLIPdb
Alias
HNRPC
Class
protein
UniProt id
Description
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-2
| Pubmed ID | 23374342 | Journal | Cell |
|---|---|---|---|
| Title | Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. | ||
| Author | Zarnack K, König J, Tajnik M, Martincorena I, Eustermann S, Stévant I, Reyes A, Anders S, Luscombe NM, Ule J | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 465275 | chr1:6247321-6247361 | 0.00385 |
| 465915 | chr1:6249161-6249181 | 0.0027 |
| 465925 | chr1:6249401-6249421 | 0.02635 |
| 465933 | chr1:6249561-6249581 | 0.03765 |
| 465967 | chr1:6249921-6249941 | 0.0005 |
| 466010 | chr1:6250921-6250941 | 0.00215 |
| 466025 | chr1:6251081-6251101 | 0.00205 |
| 466185 | chr1:6254741-6254761 | 0.0138 |
| 466186 | chr1:6254901-6254921 | 0.10895 |
| 466188 | chr1:6255601-6255621 | 0.1045 |
| 466251 | chr1:6258901-6258921 | 0.00385 |