Interaction Profile
Interaction ID
ncRI-40085616
Interaction Molecules
MTATP8P1 -- HNRNPU
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HeLa
Experiment
CLIP-Seq
Description
Genome-wide analysis by CLIP-seq reveals that hnRNP U binds virtually to all classes of regulatory non-coding RNAs,;CLIPseq data were analysed by CLIPdb
Molecule Profile
Alias
HNRPU;hnRNPU;hnRNP U
Class
protein
UniProt id
Description
Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single-stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity).
Reference Information
| Pubmed ID | 22325991 | Journal | Molecular cell |
|---|---|---|---|
| Title | Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. | ||
| Author | Xiao R, Tang P, Yang B, Huang J, Zhou Y, Shao C, Li H, Sun H, Zhang Y, Fu XD | ||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 438602 | chr1:569361-569401 | 0.975875 |
| 438606 | chr1:569361-569421 | 0.983416666667 |
| 439135 | chr1:569841-569861 | 0.99845 |
Network View