Interaction Profile
Interaction ID
ncRI-40054210
Interaction Molecules
Malat1 -- Nova1
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Mus musculus
Tissue or Cell Type
mouse brain
Experiment
HITS-CLIP
Description
Genome-wide analysis of these crosslinking-induced mutation sites (CIMS) in HITS-CLIP data for Nova and Argonaute (Ago) proteins in mouse brain tissue revealed Nova and Ago binding sites.
Molecule Profile
Alias
-
Class
protein
UniProt id
Description
Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion. It binds specifically to the sequence UCAUY. Most likely acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer.
Reference Information
| Pubmed ID | 20558669 | Journal | Science (New York, N.Y.) |
|---|---|---|---|
| Title | Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls. | ||
| Author | Zhang C, Frias MA, Mele A, Ruggiu M, Eom T, Marney CB, Wang H, Licatalosi DD, Fak JJ, Darnell RB | ||
| Pubmed ID | 21633356 | Journal | Nature biotechnology |
|---|---|---|---|
| Title | Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. | ||
| Author | Zhang C, Darnell RB | ||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 1464522 | chr19:5797874-5797895 | 0.994571428571 |
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| Malat1 | acquired immunodeficiency syndrome | MNDR Database |
| Malat1 | Alzheimer's disease | MNDR Database |
| Malat1 | amyotrophic lateral sclerosis | MNDR Database |
| Malat1 | B-cell lymphoma | MNDR Database |
| Malat1 | bladder urothelial carcinoma | MNDR Database |
| Malat1 | breast cancer | MNDR Database |
| Malat1 | cancer | MNDR Database |
| Malat1 | Carcinoma, Endometrioid | MNDR Database |
| Malat1 | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| Malat1 | colon cancer | MNDR Database |
| Malat1 | colorectal cancer | MNDR Database |
| Malat1 | Congenital Microtia | MNDR Database |
| Malat1 | decreased myogenesis | MNDR Database |
| Malat1 | diabetes mellitus | LncRNADisease Database |
| Malat1 | diabetes mellitus | MNDR Database |
| Malat1 | Diabetic Cardiomyopathies | MNDR Database |
| Malat1 | endometrial stromal sarcoma | MNDR Database |
| Malat1 | esophageal cancer | MNDR Database |
| Malat1 | fatty liver disease | MNDR Database |
| Malat1 | Fibroma | MNDR Database |
| Malat1 | fibrosarcoma | MNDR Database |
| Malat1 | gallbladder cancer | MNDR Database |
| Malat1 | Glioblastoma | MNDR Database |
| Malat1 | hepatocellular carcinoma | MNDR Database |
| Malat1 | histiocytoid hemangioma | MNDR Database |
| Malat1 | HIV | MNDR Database |
| Malat1 | Huntington's disease | MNDR Database |
| Malat1 | Hyperglycemia | MNDR Database |
| Malat1 | kidney cancer | MNDR Database |
| Malat1 | laryngeal squamous cell carcinoma | MNDR Database |
| Malat1 | liver cirrhosis | MNDR Database |
| Malat1 | Liver Neoplasms | MNDR Database |
| Malat1 | lung adenocarcinoma | MNDR Database |
| Malat1 | lung cancer | MNDR Database |
| Malat1 | lung small cell carcinoma | MNDR Database |
| Malat1 | lymphoma | MNDR Database |
| Malat1 | malignant glioma | MNDR Database |
| Malat1 | melanoma | MNDR Database |
| Malat1 | multiple myeloma | MNDR Database |
| Malat1 | nasopharynx carcinoma | MNDR Database |
| Malat1 | neuroblastoma | MNDR Database |
| Malat1 | non-small cell lung carcinoma | MNDR Database |
| Malat1 | oral squamous cell carcinoma | MNDR Database |
| Malat1 | osteosarcoma | MNDR Database |
| Malat1 | ovarian endometrial cancer | MNDR Database |
| Malat1 | Ovarian Neoplasms | MNDR Database |
| Malat1 | pancreatic cancer | MNDR Database |
| Malat1 | pancreatic carcinoma | MNDR Database |
| Malat1 | pancreatic ductal adenocarcinoma | MNDR Database |
| Malat1 | papillary thyroid carcinoma | MNDR Database |
| Malat1 | Parkinson's disease | MNDR Database |
| Malat1 | pituitary adenoma | MNDR Database |
| Malat1 | pre-eclampsia | MNDR Database |
| Malat1 | primary pulmonary hypertension | MNDR Database |
| Malat1 | proliferative vitreoretinopathy | MNDR Database |
| Malat1 | prostat | MNDR Database |
| Malat1 | Prostatic Neoplasms | MNDR Database |
| Malat1 | renal cell carcinoma | MNDR Database |
| Malat1 | renal clear cell carcinoma | MNDR Database |
| Malat1 | retinal degeneration | MNDR Database |
| Malat1 | Seizures | MNDR Database |
| Malat1 | squamous cell carcinoma | MNDR Database |
| Malat1 | stomach cancer | MNDR Database |
| Malat1 | TDP-43 protein, human | MNDR Database |
| Malat1 | thyroid cancer | MNDR Database |
| Malat1 | tongue squamous cell carcinoma | MNDR Database |
| Malat1 | triple-receptor negative breast cancer | MNDR Database |
| Malat1 | urinary bladder cancer | MNDR Database |
| Malat1 | Urinary Bladder Neoplasms | MNDR Database |
| Malat1 | uterine cancer | MNDR Database |
| Malat1 | uterine corpus endometrial stromal sarcoma | MNDR Database |
| Malat1 | Uterine Cervical Neoplasms | MNDR Database |
| Malat1 | uveal melanoma | MNDR Database |
| Malat1 | vulva squamous cell carcinoma | MNDR Database |