Interaction ID
ncRI-40038003
Interaction Molecules
PARP1 -- AGO2
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
BCBL1Rta
Experiment
HITS-CLIP
Description
Original Ago HITS-CLIP data of BC-3 and BCBL-1 cell lines
Alias
AGO
Class
protein
UniProt id
Description
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA
| Pubmed ID | 25648438 | Journal | Pathology oncology research : POR |
|---|---|---|---|
| Title | Identification of Target Genes Regulated by KSHV miRNAs in KSHV-Infected Lymphoma Cells. | ||
| Author | Quan L, Qiu T, Liang J, Li M, Zhang Y, Tao K | ||
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 228338 | chr1:226550798-226550862 | 0.954859375 |